Applying genetics in inflammatory disease drug discovery

Lasse Folkersen, Shameek Biswas, Klaus Stensgaard Frederiksen, Pernille Keller, Brian Fox, Jan Fleckner

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    Recent groundbreaking work in genetics has identified thousands of small-effect genetic variants throughout the genome that are associated with almost all major diseases. These genome-wide association studies (GWAS) are often proposed as a source of future medical breakthroughs. However, with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has proven arduous, and few examples of actual contributions to drug discovery exist. Here, we discuss novel approaches of overcoming this hurdle by using instead public genetics resources as a pragmatic guide alongside existing drug discovery methods. Our aim is to evaluate human genetic confidence as a rationale for drug target selection.
    Original languageEnglish
    JournalDrug Discovery Today
    Issue number10
    Pages (from-to)1176-1181
    Number of pages6
    Publication statusPublished - 2015

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