Organic synthesis (incorporating both chemo-catalysis and biocatalysis) is essential for the production of a wide range of small-molecule pharmaceuticals. However, traditional production processes are mainly based on batch and semi-batch operating modes, which have disadvantages from an economic, environmental and manufacturing perspective. A potential solution to resolve these issues is to use flow chemistry in such processes, preferably with applications of micro-and mini-sized equipment. In addition, Process Analytical Technology (PAT) may be implemented in a very efficient way in such equipment due to the high degree of automation and process controllability that can be achieved in small scale continuous equipment.
|Journal||Chimica Oggi – Chemistry Today|
|Publication status||Published - 2013|
- Flow chemistry
- Organic Synthesis
- Process Analytical Technology (PAT)
- Microreactor Technology