Applications, benefits and challenges of flow chemistry

Aleksandar Mitic, Søren Heintz, Rolf Hoffmeyer Ringborg, Vijaya Krishna Bodla, John Woodley, Krist Gernaey

Research output: Contribution to journalJournal articleResearchpeer-review


Organic synthesis (incorporating both chemo-catalysis and biocatalysis) is essential for the production of a wide range of small-molecule pharmaceuticals. However, traditional production processes are mainly based on batch and semi-batch operating modes, which have disadvantages from an economic, environmental and manufacturing perspective. A potential solution to resolve these issues is to use flow chemistry in such processes, preferably with applications of micro-and mini-sized equipment. In addition, Process Analytical Technology (PAT) may be implemented in a very efficient way in such equipment due to the high degree of automation and process controllability that can be achieved in small scale continuous equipment.
Original languageEnglish
JournalChimica Oggi – Chemistry Today
Issue number4
Pages (from-to)4-8
Publication statusPublished - 2013


  • Flow chemistry
  • Organic Synthesis
  • Biocatalysis
  • Process Analytical Technology (PAT)
  • Microreactor Technology


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