### Abstract

The optimisation of a volume-based FI-HG-GFAAS procedure is
described for the trace determination of Ge, comprising in situ
collection of the generated germane in the graphite furnace. The
response function is the peak area readout (A*s). Based on a
preliminary study, where factorial designs were used to identify
significant factors and interactions, the procedure was optimised
using both simplex and OVAT (one variable at the time) methods.
The characteristics and merits of these methods are discussed.
Under optimal experimental conditions, using a sample volume of
100 mu-l, Ge was determined at a sampling frequency of 22 h-1. The
sensitivity, in terms of the characteristic mass, m0, was 26
pg/0.0044 A*s, with a detection limit of 0.21 mu-g/L (3 sigma).
The precision (relative standard deviation) was 2.0% (n=10) at the
1 mu-g/L level.

Original language | English |
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Journal | Fresenius' Journal of Analytical Chemistry |

Volume | 358 |

Issue number | 7-8 |

Pages (from-to) | 775-780 |

ISSN | 0937-0633 |

Publication status | Published - 1997 |

## Cite this

Hilligsøe, B., & Hansen, E. H. (1997). Application of Factorial Designs and Simplex Optimisation in
the Development of Flow Injection-Hydride Generation-Graphite
Furnace Atomic Absorption Spectrometry Procedures as
Demonstrated for the Determination of Trace Levels of Germanium.

*Fresenius' Journal of Analytical Chemistry*,*358*(7-8), 775-780.