Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent

Abdul Rahman Abdallah Al-Khalidy (Inventor), Bruce Campbell (Inventor), John Arthur Urbahn (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor), Vincent Paul Staudinger (Inventor), Jaydeep Roy (Inventor)

Research output: Patent

51 Downloads (Pure)


Provided is an apparatus and method for automated hyperpolarization of samples for use as an imaging agent comprising a sample box, an airlock chamber configured to receive a sample from the sample box, a cryogenic chamber, a guide channel to transport samples from the airlock chamber to the cryogenic chamber, a heater and pressure module coupled to the sample box, an insertion and retraction device to transport samples through the guide channel to and from the cryogenic chamber, a dissolution module coupled to the sample box, and a controller to regulate hyperpolarization of the samples by controlling one or more of position, sequencing, temperature, pressure, and dissolution of the samples within the apparatus. Also provided is a machine-readable medium comprising instruction which, when executed by a controller, causes a hyperpolarization apparatus to perform the steps of hyperpolarization of a sample.

Original languageEnglish
IPCG01V 3/ 00 A I
Patent numberUS7633290
Filing date25/03/2010
Country/TerritoryUnited States
Priority date09/09/2008
Priority numberUS20080206823
Publication statusPublished - 15 Dec 2009
Externally publishedYes

Bibliographical note

Also published as: JP5639353 (B2) US7633290 (B1) DE102009043893 (A1)


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