Apolipoprotein E deficiency increases remnant lipoproteins and accelerates progressive atherosclerosis in Yucatan minipigs

J. Shim, C. B. Poulsen, M. Hagensen, T. Larsen, P. M. H. Heegaard, C. Christoffersen, L. Bolund, M. Schmidt, Y. Liu, J. Li, R. Li, H. Callesen, J. F. Bentzon, C. B. Sørensen

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

    Abstract

    Apolipoprotein E (APOE) mediates hepatic uptake of lipoproteins through the low-density lipoprotein receptor and low-density receptor-related protein 1. Defects or deficiency of APOE causes familial dysbetalipoproteinemia in humans characterized by accumulations of VLDL, IDL, and chylomicron remnants as well as a higher risk of atherosclerotic disease. APOE is also involved in controlling smooth muscle cell proliferation and migration, reverse cholesterol transport and inflammation.
    Original languageEnglish
    JournalTransgenic Research
    Volume27
    Issue number5
    Pages (from-to)484-484
    ISSN0962-8819
    DOIs
    Publication statusPublished - 2018
    EventUC Davis Transgenic Animal Research Conference XI - e Granlibakken Conference Center and Resort, Tahoe, United States
    Duration: 13 Aug 201717 Aug 2017
    Conference number: 11

    Conference

    ConferenceUC Davis Transgenic Animal Research Conference XI
    Number11
    Locatione Granlibakken Conference Center and Resort
    CountryUnited States
    CityTahoe
    Period13/08/201717/08/2017

    Cite this

    Shim, J., Poulsen, C. B., Hagensen, M., Larsen, T., Heegaard, P. M. H., Christoffersen, C., Bolund, L., Schmidt, M., Liu, Y., Li, J., Li, R., Callesen, H., Bentzon, J. F., & Sørensen, C. B. (2018). Apolipoprotein E deficiency increases remnant lipoproteins and accelerates progressive atherosclerosis in Yucatan minipigs. Transgenic Research, 27(5), 484-484. https://doi.org/10.1007/s11248-018-0086-x