Antimicrobial susceptibility patterns of thermophilic Campylobacter spp. from humans, pigs, cattle, and broilers in Denmark

Frank Møller Aarestrup, E. M. Nielsen, Mogens Madsen, J. Engberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The MICs of 16 antimicrobial agents were determined for 202 Campylobacter jejuni isolates, 123 Campylobacter coli isolates, and 6 Campylobacter lari isolates from humans and food animals in Denmark. The C.jejuni isolates originated from humans (75), broilers (95), cattle (29), and pigs (3); the C. coil isolates originated from humans (7), broilers (17), and pigs (99); and the C. lari isolates originated from broilers (5) and cattle (1), All isolates were susceptible to apramycin, neomycin, and gentamicin, Only a few C.jejuni isolates were resistant to one or more antimicrobial agents, Resistance to tetracycline was more common among C.jejuni isolates from humans (11%) than among C, jejuni isolates from animals (0 to 2%), More resistance to streptomycin was found among C, jejuni isolates from cattle (10%) than among those from humans (4%) or broilers (1%), A greater proportion of C. coil than of C, jejuni isolates were resistant to the other antimicrobial agents tested. Isolates were in most cases either coresistant to tylosin, spiramycin, and erythromycin or susceptible to all three antibiotics, More macrolide-resistant isolates were observed among C. coil isolates from swine (79%) than among C. coil isolates from broilers (18%) and humans (14%), Twenty-four percent of C, coli isolates from pigs were resistant to enrofloxacin, whereas 29% of C, coli isolates from humans and none from broilers were resistant, More resistance to streptomycin was observed among C, coil isolates from swine (48%) than among C. coil isolates from broilers (6%) or humans (0%), The six C, lari isolates were susceptible to all antimicrobial agents except ampicillin and nalidixic acid, This study showed that antimicrobial resistance was found only at relatively low frequencies among C. jejuni and C, lari isolates, Among C. coil isolates, especially from swine, there was a high level of resistance to macrolides and streptomycin, Furthermore, this study showed differences in the resistance to antimicrobial agents among Campylobacter isolates of different origins.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number10
Pages (from-to)2244-2250
ISSN0066-4804
Publication statusPublished - 1997

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