Antimicrobial Effects of Biogenic Nanoparticles

Priyanka Singh, Abhroop Garg, Santosh Pandit, V. R. S. S. Mokkapati, Ivan Mijakovic*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Infectious diseases pose one of the greatest health challenges in the medical world. Though numerous antimicrobial drugs are commercially available, they often lack effectiveness against recently developed multidrug resistant (MDR) microorganisms. This results in high antibiotic dose administration and a need to develop new antibiotics, which in turn requires time, money, and labor investments. Recently, biogenic metallic nanoparticles have proven their effectiveness against MDR microorganisms, individually and in synergy with the current/conventional antibiotics. Importantly, biogenic nanoparticles are easy to produce, facile, biocompatible, and environmentally friendly in nature. In addition, biogenic nanoparticles are surrounded by capping layers, which provide them with biocompatibility and long-term stability. Moreover, these capping layers provide an active surface for interaction with biological components, facilitated by free active surface functional groups. These groups are available for modification, such as conjugation with antimicrobial drugs, genes, and peptides, in order to enhance their efficacy and delivery. This review summarizes the conventional antibiotic treatments and highlights the benefits of using nanoparticles in combating infectious diseases.
Original languageEnglish
Article number1009
Issue number12
Number of pages19
Publication statusPublished - 2018


  • Antibiotics
  • Nanoparticles
  • Biogenic nanoparticles
  • Antimicrobial
  • Antibiotic resistance
  • Multidrug resistant (MDR) microorganisms


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