Antigen presenting scaffolds for immune-cell manipulation

Sine Reker Hadrup (Inventor), Vibeke Mindahl Rafa (Inventor), Søren Nyboe Jakobsen (Inventor)

    Research output: Patent

    209 Downloads (Pure)


    The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.
    Original languageEnglish
    Patent numberWO2018115146
    Filing date28/06/2018
    Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date21/12/2016
    Priority numberEP20160205918
    Publication statusPublished - 2018


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