Antigen presenting scaffolds for immune-cell manipulation

Sine Reker Hadrup (Inventor), Vibeke Mindahl Rafa (Inventor), Søren Nyboe Jakobsen (Inventor)

    Research output: Patent

    136 Downloads (Pure)

    Abstract

    The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.
    Original languageEnglish
    IPCA61K39/00
    Patent numberWO2018115146
    Filing date28/06/2018
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date21/12/2016
    Priority numberEP20160205918
    Publication statusPublished - 2018

    Cite this

    Hadrup, S. R., Rafa, V. M., & Jakobsen, S. N. (2018). IPC No. A61K39/00. Antigen presenting scaffolds for immune-cell manipulation. (Patent No. WO2018115146 ).
    Hadrup, Sine Reker (Inventor) ; Rafa, Vibeke Mindahl (Inventor) ; Jakobsen, Søren Nyboe (Inventor). / Antigen presenting scaffolds for immune-cell manipulation. IPC No.: A61K39/00. Patent No.: WO2018115146 . Jun 28, 2018.
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    author = "Hadrup, {Sine Reker} and Rafa, {Vibeke Mindahl} and Jakobsen, {S{\o}ren Nyboe}",
    year = "2018",
    language = "English",
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    note = "WO2018115146 ; A61K39/00",

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    Hadrup, SR, Rafa, VM & Jakobsen, SN Jun. 28 2018, Antigen presenting scaffolds for immune-cell manipulation, Patent No. WO2018115146 , IPC No. A61K39/00.

    Antigen presenting scaffolds for immune-cell manipulation. / Hadrup, Sine Reker (Inventor); Rafa, Vibeke Mindahl (Inventor); Jakobsen, Søren Nyboe (Inventor).

    IPC No.: A61K39/00. Patent No.: WO2018115146 . Jun 28, 2018.

    Research output: Patent

    TY - PAT

    T1 - Antigen presenting scaffolds for immune-cell manipulation

    AU - Hadrup, Sine Reker

    AU - Rafa, Vibeke Mindahl

    AU - Jakobsen, Søren Nyboe

    PY - 2018

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    N2 - The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.

    AB - The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.

    M3 - Patent

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    Y2 - 2018/06/28

    ER -