Antibacterial activity of marine-derived fungi

Carsten Christophersen; Oscar Crescente; Jens Christian Frisvad; Lone Gram; Joan Nielsen; Per Halfdan Nielsen; Lisa Rahbæk

doi:10.1023/A:1006961500325

Antibacterial activity of marine-derived fungi

Carsten Christophersen, Oscar Crescente, Jens Christian Frisvad, Lone Gram, Joan Nielsen, Per Halfdan Nielsen, Lisa Rahbæk

National Institute of Aquatic Resources

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A total of 227 marine isolates of ubiqituous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chlorofonn/methanol 3 : 2 : 1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m) including mangroves and lagoonal areas. The extracts were tested for antibacterial activity. A total of 7 were active towards Vibrio parahaenzolyticus and 55 towards Staphylococcus aureus, representing 18 different fungal species from 8 ascomycetous genera. For 61 strains of Penicillium citrinum antibacterial activity correlated well with content of secondary metabolites as measured by HPLC. Thirteen isolates of Penicillium steckii produced very similar profiles of secondary metabolites and 6 of these had activity against either V. parahaemolyticus or S. aureus or both.

Original language	English
Journal	Mycopathologia
Volume	143
Issue number	3
Pages (from-to)	135-138
ISSN	0301-486X
DOIs	https://doi.org/10.1023/A:1006961500325
Publication status	Published - 1998

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title = "Antibacterial activity of marine-derived fungi",

abstract = "A total of 227 marine isolates of ubiqituous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chlorofonn/methanol 3 : 2 : 1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m) including mangroves and lagoonal areas. The extracts were tested for antibacterial activity. A total of 7 were active towards Vibrio parahaenzolyticus and 55 towards Staphylococcus aureus, representing 18 different fungal species from 8 ascomycetous genera. For 61 strains of Penicillium citrinum antibacterial activity correlated well with content of secondary metabolites as measured by HPLC. Thirteen isolates of Penicillium steckii produced very similar profiles of secondary metabolites and 6 of these had activity against either V. parahaemolyticus or S. aureus or both.",

author = "Carsten Christophersen and Oscar Crescente and Frisvad, {Jens Christian} and Lone Gram and Joan Nielsen and Nielsen, {Per Halfdan} and Lisa Rahb{\ae}k",

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T1 - Antibacterial activity of marine-derived fungi

AU - Christophersen, Carsten

AU - Crescente, Oscar

AU - Frisvad, Jens Christian

AU - Gram, Lone

AU - Nielsen, Joan

AU - Nielsen, Per Halfdan

AU - Rahbæk, Lisa

PY - 1998

Y1 - 1998

N2 - A total of 227 marine isolates of ubiqituous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chlorofonn/methanol 3 : 2 : 1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m) including mangroves and lagoonal areas. The extracts were tested for antibacterial activity. A total of 7 were active towards Vibrio parahaenzolyticus and 55 towards Staphylococcus aureus, representing 18 different fungal species from 8 ascomycetous genera. For 61 strains of Penicillium citrinum antibacterial activity correlated well with content of secondary metabolites as measured by HPLC. Thirteen isolates of Penicillium steckii produced very similar profiles of secondary metabolites and 6 of these had activity against either V. parahaemolyticus or S. aureus or both.

AB - A total of 227 marine isolates of ubiqituous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chlorofonn/methanol 3 : 2 : 1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m) including mangroves and lagoonal areas. The extracts were tested for antibacterial activity. A total of 7 were active towards Vibrio parahaenzolyticus and 55 towards Staphylococcus aureus, representing 18 different fungal species from 8 ascomycetous genera. For 61 strains of Penicillium citrinum antibacterial activity correlated well with content of secondary metabolites as measured by HPLC. Thirteen isolates of Penicillium steckii produced very similar profiles of secondary metabolites and 6 of these had activity against either V. parahaemolyticus or S. aureus or both.

U2 - 10.1023/A:1006961500325

DO - 10.1023/A:1006961500325

M3 - Journal article

SN - 0301-486X

VL - 143

SP - 135

EP - 138

JO - Mycopathologia

JF - Mycopathologia

IS - 3

ER -

Antibacterial activity of marine-derived fungi

Abstract

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