Anisotropic magnetoresistance (AMR) and Hall effect have been studied for the (110)-oriented Nd0.48Sr0.52MnO3 film. The most remarkable results are the significant enhancement of the AMR accompanying the orbital ordering and the appearance of four-fold symmetry of the AMR along the [1-10] direction. Analysis of the Hall data indicates the absence of any visible increase in spin-orbit coupling corresponding to the AMR growth. This suggests a different mechanism for the AMR of Nd0.48Sr0.52MnO3 from that of the conventional ferromagnetic metals/alloys. © 2011 American Institute of Physics.