Animal Testing for Acute Inhalation Toxicity: A Thing of the Past?

Emilie Da Silva*, Jorid Birkelund Sørli

*Corresponding author for this work

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According to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), testing for acute inhalation toxicity is required for chemicals manufactured or imported at tonnages ≥ 10 tons per year. Three OECD test guidelines for acute inhalation toxicity in vivo are adopted (TG 403, TG 436, and TG 433). Since animal testing is ethically, scientifically and economically questionable, adoption of alternative methods by the European Union and the OECD is needed. An in vitro system based on the study of lung surfactant function is introduced.
Original languageEnglish
JournalApplied in Vitro Toxicology
Issue number2
Number of pages2
Publication statusPublished - 2018


  • Acute inhalation toxicity
  • Animal testing
  • Lung surfactant
  • Regulatory testing


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