Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities

Jeppe Madura Larsen*, Katrine Lindholm Bøgh

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

98 Downloads (Pure)

Abstract

Food allergy is an adverse reaction to otherwise harmless proteins in food. The disease is a major health problem of growing concern, affecting approximately 5‐8% of young children and 2‐4% of adults. No accepted strategy exists for prevention and treatment of food allergy, and strict avoidance of the offending food is presently the only viable management option. Living with food avoidance may have a huge impact on the quality of life of food allergic patients, with daily fear of serious or even fatal reactions. The urgent need for safe and efficient food allergy treatment options has led to massive research efforts to develop and improve strategies for food allergy immunotherapeutic approaches. A first step in developing new and improved strategies of immunotherapy often involves the use of animal models. In present review, we provide an overview of animal studies of allergen‐specific immunotherapy highlighting opportunities and challenges for each approach. The presented models, almost exclusively performed in mice, assess therapeutic efficacy and immunological outcomes following oral, intraperitoneal, subcutaneous, epicutaneous, and sublingual administration of native allergens, or preparations of hydrolyzed allergen, T cell directed peptides, or allergen with immunomodulatory adjuvants. Recently, approaches using immune cell therapy have demonstrated efficacy. Current models mainly assess anaphylaxis as the primary clinical outcome. With the increased appreciation that food allergy is a heterogeneous disease presenting different phenotypes, there is a continued need to develop new disease‐relevant therapeutic models of food allergy.
Original languageEnglish
JournalClinical and Experimental Allergy
Volume48
Issue number10
Pages (from-to)1255-1274
ISSN0954-7894
DOIs
Publication statusPublished - 2018

Keywords

  • Animal models
  • Food allergy
  • Immunotherapy
  • Desensitization
  • Tolerance induction

Cite this

@article{150ef72e9248407f993f2405a7d591c3,
title = "Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities",
abstract = "Food allergy is an adverse reaction to otherwise harmless proteins in food. The disease is a major health problem of growing concern, affecting approximately 5‐8{\%} of young children and 2‐4{\%} of adults. No accepted strategy exists for prevention and treatment of food allergy, and strict avoidance of the offending food is presently the only viable management option. Living with food avoidance may have a huge impact on the quality of life of food allergic patients, with daily fear of serious or even fatal reactions. The urgent need for safe and efficient food allergy treatment options has led to massive research efforts to develop and improve strategies for food allergy immunotherapeutic approaches. A first step in developing new and improved strategies of immunotherapy often involves the use of animal models. In present review, we provide an overview of animal studies of allergen‐specific immunotherapy highlighting opportunities and challenges for each approach. The presented models, almost exclusively performed in mice, assess therapeutic efficacy and immunological outcomes following oral, intraperitoneal, subcutaneous, epicutaneous, and sublingual administration of native allergens, or preparations of hydrolyzed allergen, T cell directed peptides, or allergen with immunomodulatory adjuvants. Recently, approaches using immune cell therapy have demonstrated efficacy. Current models mainly assess anaphylaxis as the primary clinical outcome. With the increased appreciation that food allergy is a heterogeneous disease presenting different phenotypes, there is a continued need to develop new disease‐relevant therapeutic models of food allergy.",
keywords = "Animal models, Food allergy, Immunotherapy, Desensitization, Tolerance induction",
author = "Larsen, {Jeppe Madura} and B{\o}gh, {Katrine Lindholm}",
year = "2018",
doi = "10.1111/cea.13212",
language = "English",
volume = "48",
pages = "1255--1274",
journal = "Clinical and Experimental Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "10",

}

Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities. / Larsen, Jeppe Madura; Bøgh, Katrine Lindholm.

In: Clinical and Experimental Allergy, Vol. 48, No. 10, 2018, p. 1255-1274.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities

AU - Larsen, Jeppe Madura

AU - Bøgh, Katrine Lindholm

PY - 2018

Y1 - 2018

N2 - Food allergy is an adverse reaction to otherwise harmless proteins in food. The disease is a major health problem of growing concern, affecting approximately 5‐8% of young children and 2‐4% of adults. No accepted strategy exists for prevention and treatment of food allergy, and strict avoidance of the offending food is presently the only viable management option. Living with food avoidance may have a huge impact on the quality of life of food allergic patients, with daily fear of serious or even fatal reactions. The urgent need for safe and efficient food allergy treatment options has led to massive research efforts to develop and improve strategies for food allergy immunotherapeutic approaches. A first step in developing new and improved strategies of immunotherapy often involves the use of animal models. In present review, we provide an overview of animal studies of allergen‐specific immunotherapy highlighting opportunities and challenges for each approach. The presented models, almost exclusively performed in mice, assess therapeutic efficacy and immunological outcomes following oral, intraperitoneal, subcutaneous, epicutaneous, and sublingual administration of native allergens, or preparations of hydrolyzed allergen, T cell directed peptides, or allergen with immunomodulatory adjuvants. Recently, approaches using immune cell therapy have demonstrated efficacy. Current models mainly assess anaphylaxis as the primary clinical outcome. With the increased appreciation that food allergy is a heterogeneous disease presenting different phenotypes, there is a continued need to develop new disease‐relevant therapeutic models of food allergy.

AB - Food allergy is an adverse reaction to otherwise harmless proteins in food. The disease is a major health problem of growing concern, affecting approximately 5‐8% of young children and 2‐4% of adults. No accepted strategy exists for prevention and treatment of food allergy, and strict avoidance of the offending food is presently the only viable management option. Living with food avoidance may have a huge impact on the quality of life of food allergic patients, with daily fear of serious or even fatal reactions. The urgent need for safe and efficient food allergy treatment options has led to massive research efforts to develop and improve strategies for food allergy immunotherapeutic approaches. A first step in developing new and improved strategies of immunotherapy often involves the use of animal models. In present review, we provide an overview of animal studies of allergen‐specific immunotherapy highlighting opportunities and challenges for each approach. The presented models, almost exclusively performed in mice, assess therapeutic efficacy and immunological outcomes following oral, intraperitoneal, subcutaneous, epicutaneous, and sublingual administration of native allergens, or preparations of hydrolyzed allergen, T cell directed peptides, or allergen with immunomodulatory adjuvants. Recently, approaches using immune cell therapy have demonstrated efficacy. Current models mainly assess anaphylaxis as the primary clinical outcome. With the increased appreciation that food allergy is a heterogeneous disease presenting different phenotypes, there is a continued need to develop new disease‐relevant therapeutic models of food allergy.

KW - Animal models

KW - Food allergy

KW - Immunotherapy

KW - Desensitization

KW - Tolerance induction

U2 - 10.1111/cea.13212

DO - 10.1111/cea.13212

M3 - Journal article

C2 - 29920810

VL - 48

SP - 1255

EP - 1274

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 10

ER -