Angiotensin Converting Enzyme (ACE) Inhibitors from Jasminum azoricum and Jasminum grandiflorum

Brinda Somanadhan, Ulla Wagner Smitt, V. George, P. Pushpangadan, S. Rajasekharan, Jens Øllgaard Duus, Ulf Nyman, Carl Erik Olsen, Jerzy W. Jaroszewski

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Abstract

Bioactivity-guided fractionation of extracts of the aerial parts of jasminum azoricum var. travancorense, using an in vitro ACE inhibition assay, led to isolation of three oligomeric, indoid- type compounds, which were named sambacein I—Ill. Their structures are based on spectroscopic and chemical evidence. Similarly, fractionation of extracts of aerial parts of j. grandiflorum resulted in the isolation of the previously reported ACE inhibitor, oleacein. The IC50 values of purified ACE inhibitors were 26—36 μM. Moreover, 2-(3,4-dihydroxyphenyl)- ethanol, isoquercitrin and ursolic acid were isolated from j. grandiflorum. Sambaceins and oleacein are formed from genuine iridoid glucosides during processing of the plant material. NMR spectroscopy was used to measure the level of the ACE inhibitors in the traditional medicines prepared in Kerala from these jasminum species.
Original languageEnglish
JournalPlanta Medica
Volume64
Pages (from-to)246-250
ISSN0032-0943
Publication statusPublished - 1998
Externally publishedYes

Cite this

Somanadhan, B., Wagner Smitt, U., George, V., Pushpangadan, P., Rajasekharan, S., Duus, J. Ø., Nyman, U., Olsen, C. E., & Jaroszewski, J. W. (1998). Angiotensin Converting Enzyme (ACE) Inhibitors from Jasminum azoricum and Jasminum grandiflorum. Planta Medica, 64, 246-250.