Analytical techniques and quality control in biomedical trace element research

K. Heydorn

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The small number of analytical results in trace element research calls for special methods of quality control. It is shown that when the analytical methods are in statistical control, only small numbers of duplicate or replicate results are needed to ascertain the absence of systematic errors caused by sample contamination or interference from other elements. The distribution of determinations of Cu in chorion villi from normal pregnant women is used as an example, and after screening it proved to be closely approximated by a logarithmic normal distribution with a mean value of 0.6 mg/kg. Measurement compatibility is obtained by control of traceability to certified reference materials, (C) 1994 Wiley-Liss, Inc.
    Original languageEnglish
    JournalThe Journal of Trace Elements in Experimental Medicine
    Volume7
    Issue number1
    Pages (from-to)33-38
    ISSN0896-548X
    Publication statusPublished - 1994

    Keywords

    • CHORION VILLI
    • CONTAMINATION CONTROL
    • INTERFERENCE CONTROL
    • REFERENCE MATERIALS
    • TRACEABILITY

    Cite this