Analysis of the noise-induced bursting-spiking transition in a pancreatic beta-cell model

J. Aguirre, Erik Mosekilde, M.A.F. Sanjuan

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Abstract

A stochastic model of the electrophysiological behavior of the pancreatic beta cell is studied, as a paradigmatic example of a bursting biological cell embedded in a noisy environment. The analysis is focused on the distortion that a growing noise causes to the basic properties of the membrane potential signals, such as their periodic or chaotic nature, and their bursting or spiking behavior. We present effective computational tools to obtain as much information as possible from these signals, and we suggest that the methods could be applied to real time series. Finally, a universal dependence of the main characteristics of the membrane potential on the size of the considered cell cluster is presented.
Original languageEnglish
JournalPhysical Review E. Statistical, Nonlinear, and Soft Matter Physics
Volume69
Issue number4
Pages (from-to)041910
ISSN1063-651X
DOIs
Publication statusPublished - 2004

Bibliographical note

Copyright (2004) American Physical Society.

Keywords

  • CLUSTERS
  • LYAPUNOV EXPONENTS
  • ISLETS
  • TIME-SERIES
  • CROSSING INTERSPIKE INTERVALS
  • HETEROGENEITY
  • BIFURCATION
  • RECONSTRUCTION
  • OSCILLATIONS
  • MOUSE

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