Analysis of the Degradome with the CLIP-CHIP™ Microarray

Reinhild Kappelhoff; Ulrich auf dem Keller; Christopher M. Overall

doi:10.1007/978-1-60327-299-5 10

Analysis of the Degradome with the CLIP-CHIP™ Microarray

Reinhild Kappelhoff, Ulrich auf dem Keller, Christopher M. Overall

University of British Columbia

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

The degradome microarray – CLIP-CHIP™ – is a dedicated and focused array that allows the analysis of all proteases, non-proteolytic homologs, and protease inhibitor gene transcripts in the human and murine genomes at the mRNA transcript level.

Based on unique 70-mer oligonucleotides, designed to match parts of the sequence of known or predicted protease and inhibitor mRNAs in both species and printed on a glass-matrix surface, the CLIP-CHIP™ microarray can be used to analyze differentially expressed protease and inhibitor gene products and give expression profiles for any analyzed sample.

Original language	English
Title of host publication	Matrix Metalloproteinase Protocols
Publisher	Springer
Publication date	2010
Pages	175-193
DOIs	https://doi.org/10.1007/978-1-60327-299-5 10
Publication status	Published - 2010
Externally published	Yes

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10.1007/978-1-60327-299-5 10

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abstract = "The degradome microarray – CLIP-CHIP{\texttrademark} – is a dedicated and focused array that allows the analysis of all proteases, non-proteolytic homologs, and protease inhibitor gene transcripts in the human and murine genomes at the mRNA transcript level.Based on unique 70-mer oligonucleotides, designed to match parts of the sequence of known or predicted protease and inhibitor mRNAs in both species and printed on a glass-matrix surface, the CLIP-CHIP{\texttrademark} microarray can be used to analyze differentially expressed protease and inhibitor gene products and give expression profiles for any analyzed sample.",

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AB - The degradome microarray – CLIP-CHIP™ – is a dedicated and focused array that allows the analysis of all proteases, non-proteolytic homologs, and protease inhibitor gene transcripts in the human and murine genomes at the mRNA transcript level.Based on unique 70-mer oligonucleotides, designed to match parts of the sequence of known or predicted protease and inhibitor mRNAs in both species and printed on a glass-matrix surface, the CLIP-CHIP™ microarray can be used to analyze differentially expressed protease and inhibitor gene products and give expression profiles for any analyzed sample.

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Analysis of the Degradome with the CLIP-CHIP™ Microarray

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