Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

Lise Lotte Løbger; Henning Willads Petersen; Jens Enevold Thaulov Andersen

doi:10.1080/00032710802363248

Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

Lise Lotte Løbger
, Henning Willads Petersen
, Jens Enevold Thaulov Andersen

Department of Chemistry

Technical University of Denmark
University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.

Original language	English
Journal	Analytical Letters
Volume	41
Issue number	14
Pages (from-to)	2564-2586
ISSN	0003-2719
DOIs	https://doi.org/10.1080/00032710802363248
Publication status	Published - 2008

Keywords

Blood
Gas chromatography
Headspace
Mass spectrometry

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10.1080/00032710802363248

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title = "Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS",

abstract = "An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.",

keywords = "Blood, Gas chromatography, Headspace, Mass spectrometry",

author = "L{\o}bger, \{Lise Lotte\} and Petersen, \{Henning Willads\} and Andersen, \{Jens Enevold Thaulov\}",

year = "2008",

doi = "10.1080/00032710802363248",

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journal = "Analytical Letters",

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T1 - Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

AU - Løbger, Lise Lotte

AU - Petersen, Henning Willads

AU - Andersen, Jens Enevold Thaulov

PY - 2008

Y1 - 2008

N2 - An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.

AB - An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.

KW - Blood

KW - Gas chromatography

KW - Headspace

KW - Mass spectrometry

U2 - 10.1080/00032710802363248

DO - 10.1080/00032710802363248

M3 - Journal article

SN - 0003-2719

VL - 41

SP - 2564

EP - 2586

JO - Analytical Letters

JF - Analytical Letters

IS - 14

ER -

Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

Abstract

Keywords

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