Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

Lise Lotte Løbger, Henning Willads Petersen, Jens Enevold Thaulov Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.
Original languageEnglish
JournalAnalytical Letters
Volume41
Issue number14
Pages (from-to)2564-2586
ISSN0003-2719
DOIs
Publication statusPublished - 2008

Keywords

  • Blood
  • Gas chromatography
  • Headspace
  • Mass spectrometry

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