TY - JOUR
T1 - An updated version of the Madagascar periwinkle genome
AU - Cuello, Clément
AU - Stander, Emily Amor
AU - Jansen, Hans J.
AU - Dugé De Bernonville, Thomas
AU - Oudin, Audrey
AU - Birer Williams, Caroline
AU - Lanoue, Arnaud
AU - Giglioli Guivarc'h, Nathalie
AU - Papon, Nicolas
AU - Dirks, Ron P.
AU - Jensen, Michael Krogh
AU - O'Connor, Sarah Ellen
AU - Besseau, Sébastien
AU - Courdavault, Vincent
N1 - Publisher Copyright:
Copyright: © 2022 Cuello C et al.
PY - 2022
Y1 - 2022
N2 - The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of the C. roseus genome sequence obtained through the combination of Oxford Nanopore Technologies long-reads and Illumina short-reads. This more contiguous assembly consists of 173 scaffolds with a total length of 581.128 Mb and an N50 of 12.241 Mb. Using publicly available RNAseq data, 21,061 protein coding genes were predicted and functionally annotated. A total of 42.87% of the genome was annotated as transposable elements, most of them being long-terminal repeats. Together with the increasing access to MIA-producing plant genomes, this updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution.
AB - The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of the C. roseus genome sequence obtained through the combination of Oxford Nanopore Technologies long-reads and Illumina short-reads. This more contiguous assembly consists of 173 scaffolds with a total length of 581.128 Mb and an N50 of 12.241 Mb. Using publicly available RNAseq data, 21,061 protein coding genes were predicted and functionally annotated. A total of 42.87% of the genome was annotated as transposable elements, most of them being long-terminal repeats. Together with the increasing access to MIA-producing plant genomes, this updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution.
KW - Apocynaceae
KW - Catharanthus roseus
KW - Monoterpene indole alkaloids
U2 - 10.12688/f1000research.129212.1
DO - 10.12688/f1000research.129212.1
M3 - Journal article
C2 - 36761838
AN - SCOPUS:85147789569
SN - 2046-1402
VL - 11
JO - F1000Research
JF - F1000Research
M1 - 1541
ER -
