TY - JOUR
T1 - An Intramolecular Heck reaction that Prefers a 5-endo- to a 6-exo-trig Cyclization Pathway
AU - Vital, Paulo
AU - Norrby, Per-Ola
AU - Tanner, David Ackland
PY - 2006
Y1 - 2006
N2 - A regioselective aromatic Claisen rearrangement was used to prepare 17a, the precursor of triflate 17e. The intramolecular Heck reaction of 17e is promoted only by bidentate phosphine ligands, giving exclusively and in excellent yield 20, the product of a 5-endo-trig cyclization, despite the possibility for a 6-exo-trig pathway.
AB - A regioselective aromatic Claisen rearrangement was used to prepare 17a, the precursor of triflate 17e. The intramolecular Heck reaction of 17e is promoted only by bidentate phosphine ligands, giving exclusively and in excellent yield 20, the product of a 5-endo-trig cyclization, despite the possibility for a 6-exo-trig pathway.
U2 - 10.1055/s-2006-951504
DO - 10.1055/s-2006-951504
M3 - Journal article
SN - 0936-5214
SP - 3140
EP - 3144
JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
IS - 18
ER -