An Industrial Perspective on Scale-Down Challenges Using Miniaturized Bioreactors

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Miniaturized stirred bioreactors (MSBRs) are gaining popularity as a cost-effective approach to scale-down experimentation. However, realizing conditions that reflect the large-scale process accurately can be challenging. This article highlights common challenges of using MSBRs for scale-down. The fundamental difference between oxygen mass transfer coefficient (kLa) and oxygen transfer rate scaling is addressed and the difficulty of achieving turbulent flow and industrially relevant tip speeds is described. More practical challenges of using MSBR systems for scale-down are also discussed, including the risk of vortex formation, changed volume dynamics, and wall growth. By highlighting these challenges, the article aims to create more awareness of these difficulties and to contribute to improved design of scale-down experiments.
Original languageEnglish
JournalTrends in Biotechnology
Volume37
Issue number7
Pages (from-to)697-706
Number of pages10
ISSN0167-7799
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Scale-down, Scale-up, Miniaturized stirred bioreactors, High throughput, Fermentation, Process development
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