TY - JOUR
T1 - An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity
AU - Dantoft, Thomas Meinertz
AU - Elberling, J.
AU - Brix, Susanne
AU - Szecsi, P.B.
AU - Vesterhauge, S.
AU - Skovbjerg, S.
PY - 2014
Y1 - 2014
N2 - BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P
AB - BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P
KW - Multiple chemical sensitivity
KW - Cytokines
KW - Immunological regulation
KW - Sickness behavior
KW - Case–control studies
U2 - 10.1016/j.psyneuen.2013.11.012
DO - 10.1016/j.psyneuen.2013.11.012
M3 - Journal article
C2 - 24485486
VL - 40
SP - 140
EP - 150
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -