An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity

Thomas Meinertz Dantoft, J. Elberling, Susanne Brix, P.B. Szecsi, S. Vesterhauge, S. Skovbjerg

    Research output: Contribution to journalJournal articleResearchpeer-review


    BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P
    Original languageEnglish
    Pages (from-to)140-150
    Publication statusPublished - 2014


    • Multiple chemical sensitivity
    • Cytokines
    • Immunological regulation
    • Sickness behavior
    • Case–control studies


    Dive into the research topics of 'An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity'. Together they form a unique fingerprint.

    Cite this