An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity

Thomas Meinertz Dantoft; J. Elberling; Susanne  Brix; P.B. Szecsi; S. Vesterhauge; S. Skovbjerg

doi:10.1016/j.psyneuen.2013.11.012

An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity

Thomas Meinertz Dantoft, J. Elberling, Susanne Brix, P.B. Szecsi, S. Vesterhauge, S. Skovbjerg

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P

Original language	English
Journal	Psychoneuroendocrinology
Volume	40
Pages (from-to)	140-150
ISSN	0306-4530
DOIs	https://doi.org/10.1016/j.psyneuen.2013.11.012
Publication status	Published - 2014

Keywords

Multiple chemical sensitivity
Cytokines
Immunological regulation
Sickness behavior
Case–control studies

Access to Document

10.1016/j.psyneuen.2013.11.012

Cite this

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title = "An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity",

abstract = "BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P",

keywords = "Multiple chemical sensitivity, Cytokines, Immunological regulation, Sickness behavior, Case–control studies",

author = "Dantoft, {Thomas Meinertz} and J. Elberling and Susanne Brix and P.B. Szecsi and S. Vesterhauge and S. Skovbjerg",

year = "2014",

doi = "10.1016/j.psyneuen.2013.11.012",

language = "English",

volume = "40",

pages = "140--150",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Pergamon Press",

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TY - JOUR

T1 - An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity

AU - Dantoft, Thomas Meinertz

AU - Elberling, J.

AU - Brix, Susanne

AU - Szecsi, P.B.

AU - Vesterhauge, S.

AU - Skovbjerg, S.

PY - 2014

Y1 - 2014

N2 - BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P

AB - BackgroundMultiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology. ObjectiveTo compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group. MethodBlood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study. ResultsPlasma levels of interleukin-1β, -2, -4, and -6 were significantly (P

KW - Multiple chemical sensitivity

KW - Cytokines

KW - Immunological regulation

KW - Sickness behavior

KW - Case–control studies

U2 - 10.1016/j.psyneuen.2013.11.012

DO - 10.1016/j.psyneuen.2013.11.012

M3 - Journal article

C2 - 24485486

VL - 40

SP - 140

EP - 150

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -