An autochthonous case of hepatitis C virus genotype 5a in Brazil: phylogenetic analysis

L.C. Ribeiro, F.J.D. Souto, M.P. do Espirito-Santo, Rodrigo Gouveia Oliveira, E. Lampe

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Genotype 5 of hepatitis C virus (HCV) has been rarely identified in South America. A female of African descent who never left Brazil was found to be infected by this genotype in Mato Grosso state, Central Brazil. The patient denied drug injections and revealed that she had received blood transfusions several years before. One of her blood donors was identified and tested negative for anti-HCV and HCV RNA, as were her husband and offspring. Phylogenetic analysis of the E1 and NS5B regions confirmed that this HCV strain belonged to genotype 5a. However, the E1 region analysis indicates that our strain is not closely related to any sequences of genotype 5a from other geographical areas, diverging from the African and European subclades known so far. These data suggest that genotype 5a HCV might have been circulating at a low level in Brazil longer than previously supposed.
    Original languageEnglish
    JournalArchives of Virology
    Volume154
    Issue number4
    Pages (from-to)665-670
    ISSN0304-8608
    DOIs
    Publication statusPublished - 2009

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