An Auditory Go/No-Go Study of Event-Related Potentials in Children with Fetal Alcohol Spectrum Disorders

Tobias P. Steinmann, Colin M. Andrew, Carsten E. Thomsen, Troels W. Kjær, Ernesta M. Meintjes, Christopher D. Molteno, Joseph L. Jacobson, Sandra W. Jacobson, Helge Bjarup Dissing Sørensen

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Abstract

Abstract—In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12:8years (11years to 14:7years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n = 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n = 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.
Original languageEnglish
Title of host publicationIEEE Engineering in medicine and biology society conference proceedings
PublisherIEEE
Publication date2011
Pages789-792
ISBN (Print)978-1-4244-4122-8
DOIs
Publication statusPublished - 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Boston, Massachusetts, United States
Duration: 30 Aug 20113 Sep 2011
Conference number: 33
http://embc2011.embs.org/

Conference

Conference33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Number33
Country/TerritoryUnited States
CityBoston, Massachusetts
Period30/08/201103/09/2011
Internet address

Bibliographical note

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Keywords

  • Alcoholic beverages
  • Pediatrics
  • Electroencephalography
  • Cities and towns
  • Presses
  • Educational institutions

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