TY - JOUR
T1 - An atlas of human metabolism
AU - Robinson, Jonathan L.
AU - Kocabaş, Pınar
AU - Wang, Hao
AU - Cholley, Pierre Etienne
AU - Cook, Daniel
AU - Nilsson, Avlant
AU - Anton, Mihail
AU - Ferreira, Raphael
AU - Domenzain, Iván
AU - Billa, Virinchi
AU - Limeta, Angelo
AU - Hedin, Alex
AU - Gustafsson, Johan
AU - Kerkhoven, Eduard J.
AU - Svensson, L. Thomas
AU - Palsson, Bernhard O.
AU - Mardinoglu, Adil
AU - Hansson, Lena
AU - Uhlén, Mathias
AU - Nielsen, Jens
PY - 2020
Y1 - 2020
N2 - Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.
AB - Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.
U2 - 10.1126/scisignal.aaz1482
DO - 10.1126/scisignal.aaz1482
M3 - Journal article
C2 - 32209698
SN - 1945-0877
VL - 13
JO - Science Signaling
JF - Science Signaling
IS - 624
M1 - eaaz1482
ER -