An artificial pancreas based on simple control algorithms and physiological insight

John Bagterp Jørgensen; Dimitri Boiroux; Zeinab Mahmoudi

doi:10.1016/j.ifacol.2019.06.196

An artificial pancreas based on simple control algorithms and physiological insight

John Bagterp Jørgensen
, Dimitri Boiroux
, Zeinab Mahmoudi

Research output: Contribution to journal › Conference article › Research › peer-review

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Abstract

We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

Original language	English
Book series	IFAC-PapersOnLine
Volume	52
Issue number	1
Pages (from-to)	1018-1023
ISSN	2405-8963
DOIs	https://doi.org/10.1016/j.ifacol.2019.06.196
Publication status	Published - 1 Jan 2019
Event	12th IFAC Symposium on Dynamics and Control of Process Systems - Jurerê Beach Village Hotel, Florianópolis , Brazil Duration: 23 Apr 2019 → 26 Apr 2019 Conference number: 12 https://dycopscab2019.sites.ufsc.br/

Conference

Conference	12th IFAC Symposium on Dynamics and Control of Process Systems
Number	12
Location	Jurerê Beach Village Hotel
Country/Territory	Brazil
City	Florianópolis
Period	23/04/2019 → 26/04/2019
Internet address	https://dycopscab2019.sites.ufsc.br/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Artificial pancreas
Control algorithm
Diabetes
Feed-forward control
PID
Run-to-run control

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10.1016/j.ifacol.2019.06.196

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title = "An artificial pancreas based on simple control algorithms and physiological insight",

abstract = "We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.",

keywords = "Artificial pancreas, Control algorithm, Diabetes, Feed-forward control, PID, Run-to-run control",

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N2 - We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

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KW - Artificial pancreas

KW - Control algorithm

KW - Diabetes

KW - Feed-forward control

KW - PID

KW - Run-to-run control

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DO - 10.1016/j.ifacol.2019.06.196

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An artificial pancreas based on simple control algorithms and physiological insight

Abstract

Conference

UN SDGs

Keywords

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