An artificial pancreas based on simple control algorithms and physiological insight

John Bagterp Jørgensen; Dimitri Boiroux; Zeinab Mahmoudi

doi:10.1016/j.ifacol.2019.06.196

An artificial pancreas based on simple control algorithms and physiological insight

John Bagterp Jørgensen, Dimitri Boiroux, Zeinab Mahmoudi

Research output: Contribution to journal › Conference article › Research › peer-review

308 Downloads (Orbit)

Abstract

We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

Original language	English
Book series	IFAC-PapersOnLine
Volume	52
Issue number	1
Pages (from-to)	1018-1023
ISSN	2405-8963
DOIs	https://doi.org/10.1016/j.ifacol.2019.06.196
Publication status	Published - 1 Jan 2019
Event	12th IFAC Symposium on Dynamics and Control of Process Systems - Jurerê Beach Village Hotel, Florianópolis , Brazil Duration: 23 Apr 2019 → 26 Apr 2019 Conference number: 12 https://dycopscab2019.sites.ufsc.br/

Conference

Conference	12th IFAC Symposium on Dynamics and Control of Process Systems
Number	12
Location	Jurerê Beach Village Hotel
Country/Territory	Brazil
City	Florianópolis
Period	23/04/2019 → 26/04/2019
Internet address	https://dycopscab2019.sites.ufsc.br/

Keywords

Artificial pancreas
Control algorithm
Diabetes
Feed-forward control
PID
Run-to-run control

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ifacol.2019.06.196

1 s2Final published version, 770 KB

OpenUrl availability

Full text

Cite this

@inproceedings{681e831e98924110ad97f7b90b50e4d6,

title = "An artificial pancreas based on simple control algorithms and physiological insight",

abstract = "We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.",

keywords = "Artificial pancreas, Control algorithm, Diabetes, Feed-forward control, PID, Run-to-run control",

author = "J{\o}rgensen, {John Bagterp} and Dimitri Boiroux and Zeinab Mahmoudi",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.ifacol.2019.06.196",

language = "English",

volume = "52",

pages = "1018--1023",

journal = "IFAC-PapersOnLine",

issn = "2405-8963",

publisher = "Elsevier",

number = "1",

note = "12th IFAC Symposium on Dynamics and Control of Process Systems, DYCOPS 2019 ; Conference date: 23-04-2019 Through 26-04-2019",

url = "https://dycopscab2019.sites.ufsc.br/",

}

TY - GEN

T1 - An artificial pancreas based on simple control algorithms and physiological insight

AU - Jørgensen, John Bagterp

AU - Boiroux, Dimitri

AU - Mahmoudi, Zeinab

N1 - Conference code: 12

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

AB - We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

KW - Artificial pancreas

KW - Control algorithm

KW - Diabetes

KW - Feed-forward control

KW - PID

KW - Run-to-run control

U2 - 10.1016/j.ifacol.2019.06.196

DO - 10.1016/j.ifacol.2019.06.196

M3 - Conference article

AN - SCOPUS:85070545285

SN - 2405-8963

VL - 52

SP - 1018

EP - 1023

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

IS - 1

T2 - 12th IFAC Symposium on Dynamics and Control of Process Systems

Y2 - 23 April 2019 through 26 April 2019

ER -

An artificial pancreas based on simple control algorithms and physiological insight

Abstract

Conference

Keywords

UN SDGs

Access to Document

OpenUrl availability

Fingerprint

Cite this