An artificial pancreas based on simple control algorithms and physiological insight

John Bagterp Jørgensen, Dimitri Boiroux, Zeinab Mahmoudi

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Abstract

We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.

Original languageEnglish
Book seriesIFAC-PapersOnLine
Volume52
Issue number1
Pages (from-to)1018-1023
ISSN2405-8963
DOIs
Publication statusPublished - 1 Jan 2019
Event12th IFAC Symposium on Dynamics and Control of Process Systems - Jurerê Beach Village Hotel, Florianópolis , Brazil
Duration: 23 Apr 201926 Apr 2019
Conference number: 12
https://dycopscab2019.sites.ufsc.br/

Conference

Conference12th IFAC Symposium on Dynamics and Control of Process Systems
Number12
LocationJurerê Beach Village Hotel
Country/TerritoryBrazil
CityFlorianópolis
Period23/04/201926/04/2019
Internet address

Keywords

  • Artificial pancreas
  • Control algorithm
  • Diabetes
  • Feed-forward control
  • PID
  • Run-to-run control

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