Abstract
| Original language | English |
|---|---|
| Journal | NeuroToxicology |
| Volume | 17 |
| Issue number | 3-4 |
| Pages (from-to) | 815-824 |
| ISSN | 0161-813X |
| Publication status | Published - 1998 |
Keywords
- risk assessment
- hazard assessment
- neurotoxicity criteria
- occupational hazards
- computer-based registers
Cite this
}
An approach to risk assessment. / Simonsen, L.; Lund, S. P.; Hass, Ulla.
In: NeuroToxicology, Vol. 17, No. 3-4, 1998, p. 815-824.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - An approach to risk assessment
AU - Simonsen, L.
AU - Lund, S. P.
AU - Hass, Ulla
PY - 1998
Y1 - 1998
N2 - A strategy for delineating risk factors from use of neurotoxic chemicals was applied to the Danish working environment. An analysis using this strategy disclosed the need for internationally adopted criteria for neurotoxicity, and consequently a working group was established by the Nordic Council of Ministers with the task to propose criteria for neurotoxicity. Functional effects on the nervous system, such as reduction in memory and learning ability, decrease in attention, and alteration of behavior due to toxic chemicals in the environment is now being acknowledged as an important public health problem. This change in concern from obvious effects of high dose exposure to the more subtle effects of environmental exposure to neurotoxicants was incorporated in the criteria. The new criteria for evaluating neurotoxicity data has subsequently been used on 79 common industrial chemicals. The results indicate that numerous persons are exposed in the working as well as in the general environment to several chemicals, for which almost no data on the effect on subtle neurophysiological functions are available. Development of an approach to risk assessment dealing with this problem is a major challenge in the nineties. Different approaches to risk assessment are discussed, the quality of the databases available for hazard assessment are evaluated, and the needs for further research are identified. (C) 1996 Intox Press, Inc.
AB - A strategy for delineating risk factors from use of neurotoxic chemicals was applied to the Danish working environment. An analysis using this strategy disclosed the need for internationally adopted criteria for neurotoxicity, and consequently a working group was established by the Nordic Council of Ministers with the task to propose criteria for neurotoxicity. Functional effects on the nervous system, such as reduction in memory and learning ability, decrease in attention, and alteration of behavior due to toxic chemicals in the environment is now being acknowledged as an important public health problem. This change in concern from obvious effects of high dose exposure to the more subtle effects of environmental exposure to neurotoxicants was incorporated in the criteria. The new criteria for evaluating neurotoxicity data has subsequently been used on 79 common industrial chemicals. The results indicate that numerous persons are exposed in the working as well as in the general environment to several chemicals, for which almost no data on the effect on subtle neurophysiological functions are available. Development of an approach to risk assessment dealing with this problem is a major challenge in the nineties. Different approaches to risk assessment are discussed, the quality of the databases available for hazard assessment are evaluated, and the needs for further research are identified. (C) 1996 Intox Press, Inc.
KW - risk assessment
KW - hazard assessment
KW - neurotoxicity criteria
KW - occupational hazards
KW - computer-based registers
M3 - Journal article
VL - 17
SP - 815
EP - 824
JO - NeuroToxicology
JF - NeuroToxicology
SN - 0161-813X
IS - 3-4
ER -