An alternative bioreactor concept for application of an isolated oxidoreductase for asymmetric ketone reduction

VJ Shorrock, M Chartrain, John Woodley

Research output: Contribution to journalJournal articleResearch

Abstract

In this paper an isolated NADH dependent ketone reductase has been used to synthesise (S)-6-bromo-beta-tetralol from 6-bromo-beta-tetralone, together with commercially available formate dehydrogenase (FDH) as a recycle enzyme to produce preparative quantities of the product. Furthermore, initial experiments indicate potential for an alternative bioreactor concept via the use of a resin (XAD L-323) to bind the product (and residual substrate) of the conversion rather than the cofactors or enzymes, thus allowing a new method of recycle, potentially overcoming existing problems. (C) 2003 Published by Elsevier Ltd.
Original languageEnglish
JournalTetrahedron
Volume60
Issue number3
Pages (from-to)781-788
ISSN0040-4020
DOIs
Publication statusPublished - 2004
Externally publishedYes

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