Amygdala signals subjective appetitiveness and aversiveness of mixed gambles

Sofie V. Gelskov, Susanne Henningsson, Kristoffer Hougaard Madsen, Hartwig R. Siebner, Thomas Z. Ramsoy

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Abstract

People are more sensitive to losses than to equivalent gains when making financial decisions. We used functional magnetic resonance imaging (fMRI) to illuminate how the amygdala contributes to loss aversion. The blood oxygen level dependent (BOLD) response of the amygdala was mapped while healthy individuals were responding to 50/50 gambles with varying potential gain and loss amounts. Overall, subjects demanded twice as high potential gain as loss to accept a gamble. The individual level of loss aversion was expressed by the decision boundary, i.e., the gain-loss ratio at which subjects accepted and rejected gambles with equal probability. Amygdala activity increased the more the gain-loss ratio deviated from the individual decision boundary showing that the amygdala codes action value. This response pattern was more strongly expressed in loss aversive individuals, linking amygdala activity with individual differences in loss aversion. Together, the results show that the amygdala signals subjective appetitiveness or aversiveness of gain-loss ratios at the time of choice. (C) 2015 Elsevier Ltd. All rights reserved.
Original languageEnglish
JournalCerebral Cortex
Volume66
Pages (from-to)81-90
ISSN1047-3211
DOIs
Publication statusPublished - 2015

Keywords

  • BEHAVIORAL
  • NEUROSCIENCES
  • PRIMATE AMYGDALA
  • DECISION-MAKING
  • LOSS AVERSION
  • NEURAL RESPONSES
  • PROSPECT-THEORY
  • HUMAN BRAIN
  • NEURONS
  • CHOICE
  • UNCERTAINTY
  • SENSITIVITY
  • Decision-making
  • Loss aversion
  • Amygdala
  • Ventral striatum
  • fMRI

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