Aminocyclopentanols as sugar mimics. Synthesis from unsaturated bicyclic lactones by Overman rearrangement

Marie Bøjstrup, Mette Fanefjord, Inge Lundt

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Bicyclic cyclopentane lactones, prepared from bromodeoxyaldonolactones, were transformed into aminocyclopentanols with an Overman rearrangement as the key step. Two of the compounds prepared, 7 and 19, were found to be good inhibitors of jack bean alpha-mannosidase and beta-D-N-acetylglucosaminidase, respectively.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume5
Issue number19
Pages (from-to)3164-3171
ISSN1477-0520
DOIs
Publication statusPublished - 2007

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