Amide Synthesis from Alcohols and Amines by the Extrusion of Dihydrogen

Lars Ulrik Rubæk Nordstrøm, Henning Vogt, R. Madsen

Research output: Contribution to journalJournal articlepeer-review


An environmentally friendly method for synthesis of amides is presented where a simple ruthenium catalyst mediates the direct coupling between an alcohol and an amine with the liberation of two molecules of dihydrogen. The active catalyst is generated in situ from an easily available ruthenium complex, an N-heterocyclic carbene and a phosphine. The reaction allows primary alcohols to be coupled with primary alkyamines to afford the corresponding secondary amides in good yields. The amide formation presumably proceeds through a catalytic cycle where the intermediate aldehyde and hemiaminal are both coordinated to the metal catalyst.
Original languageEnglish
JournalJournal of the American Chemical Society
Issue number52
Pages (from-to)17672-17673
Publication statusPublished - 2008


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