Alterations in the brain monoaminergic neurotransmitters of rainbow trout related to naphthalene exposure at the beginning of vitellogenesis

Research output: Contribution to journalJournal article – Annual report year: 2009Researchpeer-review

Without internal affiliation

  • Author: Gesto, Manuel

    University of Vigo

  • Author: Tintos, Adrian

  • Author: Álvarez-Otero, Rosa

  • Author: Soengas, Jose L.

  • Author: Miguez, Jesus M.

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The contents of dopamine (DA), noradrenaline (NA), serotonin (5HT), and some related metabolites were studied in different brain regions of rainbow trout at two different stages of sexual maturation (at the beginning of vitellogenesis), after naphthalene (NAP) administration. The effects of NAP varied according to duration of exposure, brain region and vitellogenesis stage of the trout, and were more significant during previtellogenesis. The changes observed in DA metabolism were generally stimulatory after exposure for 3 h, and either stimulatory or inhibitory (depending on the brain regions) after exposure for 3 days to NAP. NA levels were altered by NAP in various brain regions, but only during previtellogenesis. With respect to 5HT, treatment with NAP reduced levels of the amine and/or its main metabolite in most of the brain regions studied, particularly 3 h after treatment. The results suggest that NAP might interfere with the processes regulating brain monoamine metabolism, either locally or indirectly by altering steroid feedback to brain centres, and thus disrupt endocrine control of reproductive development through the brain-pituitary axis.
Original languageEnglish
JournalFish Physiology & Biochemistry
Volume35
Issue number3
Pages (from-to)453-465
ISSN0920-1742
DOIs
Publication statusPublished - 2009
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • BIOCHEMISTRY, FISHERIES, PHYSIOLOGY, ONCORHYNCHUS-MYKISS, HYDROXYLASE ACTIVITY, LUTEINIZING-HORMONE, STEROID-HORMONES, CRUDE-OIL, PITUITARY, DOPAMINE, METABOLISM, FEMALE, FISH, Dopamine, Serotonin, Naphthalene, Polycyclic aromatic hydrocarbons, Vitellogenesis, Trout, Life Sciences, Zoology, Animal Biochemistry, Animal Anatomy / Morphology / Histology, Animal Physiology, Freshwater & Marine Ecology, Analysis of Variance, Animals, Brain, Naphthalenes, Neurotransmitter Agents, Norepinephrine, Oncorhynchus mykiss, naphthalene, Aquatic Science, Biochemistry, Physiology, agents interacting with transmitter, hormone or drug receptors, dopamine, naphthalene derivative, noradrenalin, serotonin, analysis of variance, animal, article, brain, comparative study, drug effect, metabolism, rainbow trout, vitellogenesis, Salmonidae, endocrine control disruption, steroid feedback alteration, vitellogenesis stage, Pisces Vertebrata Chordata Animalia (Animals, Chordates, Fish, Nonhuman Vertebrates, Vertebrates) - Osteichthyes [85206] Oncorhynchus mykiss species rainbow trout common female, amine, brain monoaminergic neurotransmitter, dopamine 51-61-6 metabolism, monoamine metabolism, naphthalene 91-20-3, nor-adrenaline 51-41-2, serotonin 50-67-9, 10060, Biochemistry studies - General, 10064, Biochemistry studies - Proteins, peptides and amino acids, 13002, Metabolism - General metabolism and metabolic pathways, 16504, Reproductive system - Physiology and biochemistry, 17002, Endocrine - General, 17020, Endocrine - Neuroendocrinology, 20504, Nervous system - Physiology and biochemistry, 25502, Development and Embryology - General and descriptive, Chemical Coordination and Homeostasis, Neural Coordination, Reproduction, brain nervous system, brain-pituitary axis endocrine system, nervous system, Development, Endocrine System, Metabolism, Nervous System, Reproductive System

ID: 118743575