All-in-polymer injection molded device for single cell capture using multilevel silicon master fabrication

S. Tanzi, S.T. Larsen, M. Matteucci, R. Taboryski

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

    Abstract

    This work demonstrates a novel all-in-polymer device for single cell capture applicable for biological recordings. The chip is injection molded and comprises a "cornered" (non planar) aperture. It has been demonstrated how cornered apertures are straightforward to mold in PDMS [1,2]. In this study we demonstrate cornered apertures made in a thermoplastic polymer. One of the advantages of cornered apertures is the ease of microscopy under a standard inverted optical microscope, when using transparent materials. After the part is injection molded, the sealing of the chip is performed by thermal bonding to a polymer foil, so the complete device results from only two parts. It differs from similar devices in the novel material and fabrication platform that enables high reproducibility and inexpensive mass production. Optimization of the fabrication scheme has been carried out in order to avoid defects during demolding. Capturing of single PC12 cells has been demonstrated.
    Original languageEnglish
    Title of host publicationTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo
    Publication date2012
    Pages376-379
    Publication statusPublished - 2012
    EventNanotech 2012: Conference & Expo - Santa Clara Convention Center, Santa Clara, United States
    Duration: 18 Jun 201221 Jun 2012
    Conference number: 15

    Conference

    ConferenceNanotech 2012
    Number15
    LocationSanta Clara Convention Center
    CountryUnited States
    CitySanta Clara
    Period18/06/201221/06/2012

    Keywords

    • Dry etching
    • Exhibitions
    • Fabrication
    • Fluidics
    • Injection molding
    • Polymers
    • Nanotechnology

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