Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

Ulla A. Hvidtfeldt; Janne S. Tolstrup; Marianne Uhre Jakobsen; Berit L. Heitmann; Morten Gronbaek; Eilis O'Reilly; Katarina Balter; Uri Goldbourt; Goran Hallmans; Paul Knekt; Simin Liu; Mark Pereira; Pirjo Pietinen; Donna Spiegelman; June Stevens; Jarmo Virtamo; Walter C. Willett; Eric B. Rimm; Alberto Ascherio

doi:10.1161/CIRCULATIONAHA.109.887513

Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

Ulla A. Hvidtfeldt
, Janne S. Tolstrup
, Marianne Uhre Jakobsen
, Berit L. Heitmann
, Morten Gronbaek
, Eilis O'Reilly
, Katarina Balter
, Uri Goldbourt
, Goran Hallmans
, Paul Knekt
, Simin Liu
, Mark Pereira
, Pirjo Pietinen
, Donna Spiegelman
, June Stevens
, Jarmo Virtamo
, Walter C. Willett
, Eric B. Rimm
, Alberto Ascherio

University of Southern Denmark
Copenhagen University Hospital Herlev and Gentofte
Aarhus University Hospital
Harvard T.H. Chan School of Public Health
Karolinska Institutet
Tel Aviv University
Umeå University
National Public Health Institute Helsinki
University of Minnesota Twin Cities
University of North Carolina at Chapel Hill

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background: Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men = 60 years of age were 0.58 (95% confidence interval [CI], 0.36 to 0.93), 0.72 (95% CI, 0.60 to 0.86), and 0.85 (95% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90% CI, 44 to 140) adults. Similar results were observed in women. Conclusion: Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults.

Original language	English
Journal	Circulation Research
Volume	121
Issue number	14
Pages (from-to)	1589-1597
Number of pages	9
ISSN	0009-7330
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.109.887513
Publication status	Published - 2010
Externally published	Yes

Keywords

Age groups
Alcohol consumption
Coronary disease
Epidemiology

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10.1161/CIRCULATIONAHA.109.887513

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Hvidtfeldt, U. A., Tolstrup, J. S., Jakobsen, M. U., Heitmann, B. L., Gronbaek, M., O'Reilly, E., Balter, K., Goldbourt, U., Hallmans, G., Knekt, P., Liu, S., Pereira, M., Pietinen, P., Spiegelman, D., Stevens, J., Virtamo, J., Willett, W. C., Rimm, E. B., & Ascherio, A. (2010). Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults. Circulation Research, 121(14), 1589-1597. https://doi.org/10.1161/CIRCULATIONAHA.109.887513

@article{8e080c76df4c4a6bb0b47a40ba794ee8,

title = "Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults",

abstract = "Background: Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men = 60 years of age were 0.58 (95\% confidence interval [CI], 0.36 to 0.93), 0.72 (95\% CI, 0.60 to 0.86), and 0.85 (95\% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90\% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90\% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90\% CI, 44 to 140) adults. Similar results were observed in women. Conclusion: Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults. ",

keywords = "Age groups, Alcohol consumption, Coronary disease, Epidemiology",

author = "Hvidtfeldt, \{Ulla A.\} and Tolstrup, \{Janne S.\} and Jakobsen, \{Marianne Uhre\} and Heitmann, \{Berit L.\} and Morten Gronbaek and Eilis O'Reilly and Katarina Balter and Uri Goldbourt and Goran Hallmans and Paul Knekt and Simin Liu and Mark Pereira and Pirjo Pietinen and Donna Spiegelman and June Stevens and Jarmo Virtamo and Willett, \{Walter C.\} and Rimm, \{Eric B.\} and Alberto Ascherio",

year = "2010",

doi = "10.1161/CIRCULATIONAHA.109.887513",

language = "English",

volume = "121",

pages = "1589--1597",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

number = "14",

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Hvidtfeldt, UA, Tolstrup, JS, Jakobsen, MU, Heitmann, BL, Gronbaek, M, O'Reilly, E, Balter, K, Goldbourt, U, Hallmans, G, Knekt, P, Liu, S, Pereira, M, Pietinen, P, Spiegelman, D, Stevens, J, Virtamo, J, Willett, WC, Rimm, EB & Ascherio, A 2010, 'Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults', Circulation Research, vol. 121, no. 14, pp. 1589-1597. https://doi.org/10.1161/CIRCULATIONAHA.109.887513

TY - JOUR

T1 - Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

AU - Hvidtfeldt, Ulla A.

AU - Tolstrup, Janne S.

AU - Jakobsen, Marianne Uhre

AU - Heitmann, Berit L.

AU - Gronbaek, Morten

AU - O'Reilly, Eilis

AU - Balter, Katarina

AU - Goldbourt, Uri

AU - Hallmans, Goran

AU - Knekt, Paul

AU - Liu, Simin

AU - Pereira, Mark

AU - Pietinen, Pirjo

AU - Spiegelman, Donna

AU - Stevens, June

AU - Virtamo, Jarmo

AU - Willett, Walter C.

AU - Rimm, Eric B.

AU - Ascherio, Alberto

PY - 2010

Y1 - 2010

N2 - Background: Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men = 60 years of age were 0.58 (95% confidence interval [CI], 0.36 to 0.93), 0.72 (95% CI, 0.60 to 0.86), and 0.85 (95% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90% CI, 44 to 140) adults. Similar results were observed in women. Conclusion: Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults.

AB - Background: Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men = 60 years of age were 0.58 (95% confidence interval [CI], 0.36 to 0.93), 0.72 (95% CI, 0.60 to 0.86), and 0.85 (95% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90% CI, 44 to 140) adults. Similar results were observed in women. Conclusion: Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults.

KW - Age groups

KW - Alcohol consumption

KW - Coronary disease

KW - Epidemiology

U2 - 10.1161/CIRCULATIONAHA.109.887513

DO - 10.1161/CIRCULATIONAHA.109.887513

M3 - Journal article

SN - 0009-7330

VL - 121

SP - 1589

EP - 1597

JO - Circulation Research

JF - Circulation Research

IS - 14

ER -

Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

Abstract

Keywords

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