Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

P. Ferrari, J. D. McKay, M. Jenab, P. Brennan, F. Canzian, Ulla Birgitte Vogel, A. Tjonneland, K. Overvad, J. S. Tolstrup, M-C Boutron-Ruault, F. Clavel-Chapelon, S. Morois, R. Kaaks, H. Boeing, M. Bergmann, A. Trichopoulou, M. Katsoulis, D. Trichopoulos, V. Krogh, S. PanicoC. Sacerdote, D. Palli, R. Tumino, P. H. Peeters, C. H. van Gils, B. Bueno-de-Mesquita, A. Vrieling, E. Lund, A. Hjartaker, A. Agudo, L. R. Suarez, L. Arriola, M-D Chirlaque, E. Ardanaz, M-J Sanchez, J. Manjer, B. Lindkvist, G. Hallmans, R. Palmqvist, N. Allen, T. Key, K-T Khaw, N. Slimani, S. Rinaldi, I. Romieu, P. Boffetta, D. Romaguera, T. Norat, E. Riboli

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations.SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors.RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number12
Pages (from-to)1303-1308
ISSN0954-3007
DOIs
Publication statusPublished - 2012

Keywords

  • alcohol consumption
  • alcohol intake
  • European Prospective Investigation into Cancer and Nutrition
  • alcohol dependence Alcoholism (MeSH) behavioral and mental disorders, toxicity complications
  • colorectal cancer Colorectal Neoplasms (MeSH) digestive system disease, neoplastic disease etiology, genetics
  • Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common middle age, aged female, male Caucasian, Western-European
  • human ADH1B gene [Hominidae] human alcohol dehydrogenase 1B gene polymorphism, allele
  • human ADH7 gene [Hominidae] human alcohol dehydrogenase 7 gene polymorphism
  • human ALDH2 gene [Hominidae] human aldehyde dehydrogenase 2 gene polymorphism
  • 03502, Genetics - General
  • 03508, Genetics - Human
  • 03509, Genetics - Population genetics
  • 07004, Behavioral biology - Human behavior
  • 14006, Digestive system - Pathology
  • 15002, Blood - Blood and lymph studies
  • 15004, Blood - Blood cell studies
  • 21002, Psychiatry - Psychopathology, psychodynamics and therapy
  • 21004, Psychiatry - Addiction: alcohol, drugs, smoking
  • 22501, Toxicology - General and methods
  • 24004, Neoplasms - Pathology, clinical aspects and systemic effects
  • 24500, Gerontology
  • Biochemistry and Molecular Biophysics
  • Human Medicine, Medical Sciences
  • Population Studies
  • blood blood and lymphatics
  • Gastroenterology
  • Molecular Genetics
  • Oncology
  • Population Genetics
  • Psychiatry
  • Toxicology

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