Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

P. Ferrari; J. D. McKay; M. Jenab; P. Brennan; F. Canzian; Ulla Birgitte Vogel; A. Tjonneland; K. Overvad; J. S. Tolstrup; M-C Boutron-Ruault; F. Clavel-Chapelon; S. Morois; R. Kaaks; H. Boeing; M. Bergmann; A. Trichopoulou; M. Katsoulis; D. Trichopoulos; V. Krogh; S. Panico; C. Sacerdote; D. Palli; R. Tumino; P. H. Peeters; C. H. van Gils; B. Bueno-de-Mesquita; A. Vrieling; E. Lund; A. Hjartaker; A. Agudo; L. R. Suarez; L. Arriola; M-D Chirlaque; E. Ardanaz; M-J Sanchez; J. Manjer; B. Lindkvist; G. Hallmans; R. Palmqvist; N. Allen; T. Key; K-T Khaw; N. Slimani; S. Rinaldi; I. Romieu; P. Boffetta; D. Romaguera; T. Norat; E. Riboli

doi:10.1038/ejcn.2012.173

Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

P. Ferrari, J. D. McKay, M. Jenab, P. Brennan, F. Canzian, Ulla Birgitte Vogel, A. Tjonneland, K. Overvad, J. S. Tolstrup, M-C Boutron-Ruault, F. Clavel-Chapelon, S. Morois, R. Kaaks, H. Boeing, M. Bergmann, A. Trichopoulou, M. Katsoulis, D. Trichopoulos, V. Krogh, S. PanicoC. Sacerdote, D. Palli, R. Tumino, P. H. Peeters, C. H. van Gils, B. Bueno-de-Mesquita, A. Vrieling, E. Lund, A. Hjartaker, A. Agudo, L. R. Suarez, L. Arriola, M-D Chirlaque, E. Ardanaz, M-J Sanchez, J. Manjer, B. Lindkvist, G. Hallmans, R. Palmqvist, N. Allen, T. Key, K-T Khaw, N. Slimani, S. Rinaldi, I. Romieu, P. Boffetta, D. Romaguera, T. Norat, E. Riboli

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations.SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors.RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	12
Pages (from-to)	1303-1308
ISSN	0954-3007
DOIs	https://doi.org/10.1038/ejcn.2012.173
Publication status	Published - 2012

Keywords

alcohol consumption
alcohol intake
European Prospective Investigation into Cancer and Nutrition
alcohol dependence Alcoholism (MeSH) behavioral and mental disorders, toxicity complications
colorectal cancer Colorectal Neoplasms (MeSH) digestive system disease, neoplastic disease etiology, genetics
Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common middle age, aged female, male Caucasian, Western-European
human ADH1B gene [Hominidae] human alcohol dehydrogenase 1B gene polymorphism, allele
human ADH7 gene [Hominidae] human alcohol dehydrogenase 7 gene polymorphism
human ALDH2 gene [Hominidae] human aldehyde dehydrogenase 2 gene polymorphism
03502, Genetics - General
03508, Genetics - Human
03509, Genetics - Population genetics
07004, Behavioral biology - Human behavior
14006, Digestive system - Pathology
15002, Blood - Blood and lymph studies
15004, Blood - Blood cell studies
21002, Psychiatry - Psychopathology, psychodynamics and therapy
21004, Psychiatry - Addiction: alcohol, drugs, smoking
22501, Toxicology - General and methods
24004, Neoplasms - Pathology, clinical aspects and systemic effects
24500, Gerontology
Biochemistry and Molecular Biophysics
Human Medicine, Medical Sciences
Population Studies
blood blood and lymphatics
Gastroenterology
Molecular Genetics
Oncology
Population Genetics
Psychiatry
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Ferrari, P., McKay, J. D., Jenab, M., Brennan, P., Canzian, F., Vogel, U. B., Tjonneland, A., Overvad, K., Tolstrup, J. S., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Morois, S., Kaaks, R., Boeing, H., Bergmann, M., Trichopoulou, A., Katsoulis, M., Trichopoulos, D., Krogh, V., ... Riboli, E. (2012). Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. European Journal of Clinical Nutrition, 66(12), 1303-1308. https://doi.org/10.1038/ejcn.2012.173

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title = "Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study",

abstract = "BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations.SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors.RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff",

keywords = "alcohol consumption, alcohol intake, European Prospective Investigation into Cancer and Nutrition, alcohol dependence Alcoholism (MeSH) behavioral and mental disorders, toxicity complications, colorectal cancer Colorectal Neoplasms (MeSH) digestive system disease, neoplastic disease etiology, genetics, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common middle age, aged female, male Caucasian, Western-European, human ADH1B gene [Hominidae] human alcohol dehydrogenase 1B gene polymorphism, allele, human ADH7 gene [Hominidae] human alcohol dehydrogenase 7 gene polymorphism, human ALDH2 gene [Hominidae] human aldehyde dehydrogenase 2 gene polymorphism, 03502, Genetics - General, 03508, Genetics - Human, 03509, Genetics - Population genetics, 07004, Behavioral biology - Human behavior, 14006, Digestive system - Pathology, 15002, Blood - Blood and lymph studies, 15004, Blood - Blood cell studies, 21002, Psychiatry - Psychopathology, psychodynamics and therapy, 21004, Psychiatry - Addiction: alcohol, drugs, smoking, 22501, Toxicology - General and methods, 24004, Neoplasms - Pathology, clinical aspects and systemic effects, 24500, Gerontology, Biochemistry and Molecular Biophysics, Human Medicine, Medical Sciences, Population Studies, blood blood and lymphatics, Gastroenterology, Molecular Genetics, Oncology, Population Genetics, Psychiatry, Toxicology",

author = "P. Ferrari and McKay, {J. D.} and M. Jenab and P. Brennan and F. Canzian and Vogel, {Ulla Birgitte} and A. Tjonneland and K. Overvad and Tolstrup, {J. S.} and M-C Boutron-Ruault and F. Clavel-Chapelon and S. Morois and R. Kaaks and H. Boeing and M. Bergmann and A. Trichopoulou and M. Katsoulis and D. Trichopoulos and V. Krogh and S. Panico and C. Sacerdote and D. Palli and R. Tumino and Peeters, {P. H.} and {van Gils}, {C. H.} and B. Bueno-de-Mesquita and A. Vrieling and E. Lund and A. Hjartaker and A. Agudo and Suarez, {L. R.} and L. Arriola and M-D Chirlaque and E. Ardanaz and M-J Sanchez and J. Manjer and B. Lindkvist and G. Hallmans and R. Palmqvist and N. Allen and T. Key and K-T Khaw and N. Slimani and S. Rinaldi and I. Romieu and P. Boffetta and D. Romaguera and T. Norat and E. Riboli",

year = "2012",

doi = "10.1038/ejcn.2012.173",

language = "English",

volume = "66",

pages = "1303--1308",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

number = "12",

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Ferrari, P, McKay, JD, Jenab, M, Brennan, P, Canzian, F, Vogel, UB, Tjonneland, A, Overvad, K, Tolstrup, JS, Boutron-Ruault, M-C, Clavel-Chapelon, F, Morois, S, Kaaks, R, Boeing, H, Bergmann, M, Trichopoulou, A, Katsoulis, M, Trichopoulos, D, Krogh, V, Panico, S, Sacerdote, C, Palli, D, Tumino, R, Peeters, PH, van Gils, CH, Bueno-de-Mesquita, B, Vrieling, A, Lund, E, Hjartaker, A, Agudo, A, Suarez, LR, Arriola, L, Chirlaque, M-D, Ardanaz, E, Sanchez, M-J, Manjer, J, Lindkvist, B, Hallmans, G, Palmqvist, R, Allen, N, Key, T, Khaw, K-T, Slimani, N, Rinaldi, S, Romieu, I, Boffetta, P, Romaguera, D, Norat, T & Riboli, E 2012, 'Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study', European Journal of Clinical Nutrition, vol. 66, no. 12, pp. 1303-1308. https://doi.org/10.1038/ejcn.2012.173

Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. / Ferrari, P.; McKay, J. D.; Jenab, M. et al.
In: European Journal of Clinical Nutrition, Vol. 66, No. 12, 2012, p. 1303-1308.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

AU - Ferrari, P.

AU - McKay, J. D.

AU - Jenab, M.

AU - Brennan, P.

AU - Canzian, F.

AU - Vogel, Ulla Birgitte

AU - Tjonneland, A.

AU - Overvad, K.

AU - Tolstrup, J. S.

AU - Boutron-Ruault, M-C

AU - Clavel-Chapelon, F.

AU - Morois, S.

AU - Kaaks, R.

AU - Boeing, H.

AU - Bergmann, M.

AU - Trichopoulou, A.

AU - Katsoulis, M.

AU - Trichopoulos, D.

AU - Krogh, V.

AU - Panico, S.

AU - Sacerdote, C.

AU - Palli, D.

AU - Tumino, R.

AU - Peeters, P. H.

AU - van Gils, C. H.

AU - Bueno-de-Mesquita, B.

AU - Vrieling, A.

AU - Lund, E.

AU - Hjartaker, A.

AU - Agudo, A.

AU - Suarez, L. R.

AU - Arriola, L.

AU - Chirlaque, M-D

AU - Ardanaz, E.

AU - Sanchez, M-J

AU - Manjer, J.

AU - Lindkvist, B.

AU - Hallmans, G.

AU - Palmqvist, R.

AU - Allen, N.

AU - Key, T.

AU - Khaw, K-T

AU - Slimani, N.

AU - Rinaldi, S.

AU - Romieu, I.

AU - Boffetta, P.

AU - Romaguera, D.

AU - Norat, T.

AU - Riboli, E.

PY - 2012

Y1 - 2012

N2 - BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations.SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors.RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff

AB - BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations.SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors.RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff

KW - alcohol consumption

KW - alcohol intake

KW - European Prospective Investigation into Cancer and Nutrition

KW - alcohol dependence Alcoholism (MeSH) behavioral and mental disorders, toxicity complications

KW - colorectal cancer Colorectal Neoplasms (MeSH) digestive system disease, neoplastic disease etiology, genetics

KW - Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common middle age, aged female, male Caucasian, Western-European

KW - human ADH1B gene [Hominidae] human alcohol dehydrogenase 1B gene polymorphism, allele

KW - human ADH7 gene [Hominidae] human alcohol dehydrogenase 7 gene polymorphism

KW - human ALDH2 gene [Hominidae] human aldehyde dehydrogenase 2 gene polymorphism

KW - 03502, Genetics - General

KW - 03508, Genetics - Human

KW - 03509, Genetics - Population genetics

KW - 07004, Behavioral biology - Human behavior

KW - 14006, Digestive system - Pathology

KW - 15002, Blood - Blood and lymph studies

KW - 15004, Blood - Blood cell studies

KW - 21002, Psychiatry - Psychopathology, psychodynamics and therapy

KW - 21004, Psychiatry - Addiction: alcohol, drugs, smoking

KW - 22501, Toxicology - General and methods

KW - 24004, Neoplasms - Pathology, clinical aspects and systemic effects

KW - 24500, Gerontology

KW - Biochemistry and Molecular Biophysics

KW - Human Medicine, Medical Sciences

KW - Population Studies

KW - blood blood and lymphatics

KW - Gastroenterology

KW - Molecular Genetics

KW - Oncology

KW - Population Genetics

KW - Psychiatry

KW - Toxicology

U2 - 10.1038/ejcn.2012.173

DO - 10.1038/ejcn.2012.173

M3 - Journal article

C2 - 23149980

SN - 0954-3007

VL - 66

SP - 1303

EP - 1308

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 12

ER -

Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Abstract

Keywords

UN SDGs

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