AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment

Kothanahally S. Sharath Kumar; Yarabahally R. Girish; Milad Ashrafizadeh; Sepideh Mirzaei; Kadalipura P. Rakesh; Mohammad Hossein Gholami; Amirhossein Zabolian; Kiavash Hushmandi; Gorka Orive; Firoz Babu Kadumudi; Alireza Dolatshahi-Pirouz; Vijay Kumar Thakur; Ali Zarrabi; Pooyan Makvandi; Kanchugarakoppal S. Rangappa

doi:10.1016/j.ccr.2021.214135

AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment

Kothanahally S. Sharath Kumar^*, Yarabahally R. Girish, Milad Ashrafizadeh, Sepideh Mirzaei, Kadalipura P. Rakesh, Mohammad Hossein Gholami, Amirhossein Zabolian, Kiavash Hushmandi, Gorka Orive, Firoz Babu Kadumudi, Alireza Dolatshahi-Pirouz, Vijay Kumar Thakur, Ali Zarrabi, Pooyan Makvandi, Kanchugarakoppal S. Rangappa

^*Corresponding author for this work

Department of Health Technology

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Abstract

The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.

Original language	English
Article number	214135
Journal	Coordination Chemistry Reviews
Volume	447
Number of pages	48
ISSN	0010-8545
DOIs	https://doi.org/10.1016/j.ccr.2021.214135
Publication status	Published - 2021

Bibliographical note

Funding Information:
K.S. Rangappa acknowledge CSIR for providing an emeritus scientist fellowship. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country.

Keywords

AIE
Biomedical applications
Luminogens
Tetraphenylethylene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sharath Kumar, K. S., Girish, Y. R., Ashrafizadeh, M., Mirzaei, S., Rakesh, K. P., Hossein Gholami, M., Zabolian, A., Hushmandi, K., Orive, G., Kadumudi, F. B., Dolatshahi-Pirouz, A., Thakur, V. K., Zarrabi, A., Makvandi, P., & Rangappa, K. S. (2021). AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment. Coordination Chemistry Reviews, 447, Article 214135. https://doi.org/10.1016/j.ccr.2021.214135

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title = "AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment",

abstract = "The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.",

keywords = "AIE, Biomedical applications, Luminogens, Tetraphenylethylene",

author = "{Sharath Kumar}, {Kothanahally S.} and Girish, {Yarabahally R.} and Milad Ashrafizadeh and Sepideh Mirzaei and Rakesh, {Kadalipura P.} and {Hossein Gholami}, Mohammad and Amirhossein Zabolian and Kiavash Hushmandi and Gorka Orive and Kadumudi, {Firoz Babu} and Alireza Dolatshahi-Pirouz and Thakur, {Vijay Kumar} and Ali Zarrabi and Pooyan Makvandi and Rangappa, {Kanchugarakoppal S.}",

note = "Funding Information: K.S. Rangappa acknowledge CSIR for providing an emeritus scientist fellowship. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. ",

year = "2021",

doi = "10.1016/j.ccr.2021.214135",

language = "English",

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journal = "Coordination Chemistry Reviews",

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Sharath Kumar, KS, Girish, YR, Ashrafizadeh, M, Mirzaei, S, Rakesh, KP, Hossein Gholami, M, Zabolian, A, Hushmandi, K, Orive, G, Kadumudi, FB , Dolatshahi-Pirouz, A, Thakur, VK, Zarrabi, A, Makvandi, P & Rangappa, KS 2021, 'AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment', Coordination Chemistry Reviews, vol. 447, 214135. https://doi.org/10.1016/j.ccr.2021.214135

TY - JOUR

T1 - AIE-featured tetraphenylethylene nanoarchitectures in biomedical application

T2 - Bioimaging, drug delivery and disease treatment

AU - Sharath Kumar, Kothanahally S.

AU - Girish, Yarabahally R.

AU - Ashrafizadeh, Milad

AU - Mirzaei, Sepideh

AU - Rakesh, Kadalipura P.

AU - Hossein Gholami, Mohammad

AU - Zabolian, Amirhossein

AU - Hushmandi, Kiavash

AU - Orive, Gorka

AU - Kadumudi, Firoz Babu

AU - Dolatshahi-Pirouz, Alireza

AU - Thakur, Vijay Kumar

AU - Zarrabi, Ali

AU - Makvandi, Pooyan

AU - Rangappa, Kanchugarakoppal S.

N1 - Funding Information: K.S. Rangappa acknowledge CSIR for providing an emeritus scientist fellowship. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country.

PY - 2021

Y1 - 2021

N2 - The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.

AB - The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.

KW - AIE

KW - Biomedical applications

KW - Luminogens

KW - Tetraphenylethylene

U2 - 10.1016/j.ccr.2021.214135

DO - 10.1016/j.ccr.2021.214135

M3 - Review

AN - SCOPUS:85112756289

SN - 0010-8545

VL - 447

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

M1 - 214135

ER -

AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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