Age-dependent effects of brain stimulation on network centrality

Daria Antonenko*, Till Nierhaus, Marcus Meinzer, Kristin Prehn, Axel Thielscher, Bernd Ittermann, Agnes Flöel

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age
may mediate the effects of transcranial direct current stimulation (tDCS) on brain function.
However, studies directly comparing neural tDCS effects between young and older adults are
scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is
independent of age-related differences in performance, is well suited to investigate age
associated differential neural tDCS effects. Three “online” tDCS conditions (anodal, cathodal,
sham) were compared in a cross-over, within-subject design, in 30 young and 30 older
adults. Active stimulation targeted the left sensorimotor network (active electrode over left
sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data
analysis approach (eigenvector centrality mapping) and complementary seed-based
analyses characterized neural tDCS effects. An interaction between anodal tDCS and age
group was observed. Specifically, centrality in bilateral paracentral and posterior regions
(precuneus, superior parietal cortex) was increased in young, but decreased in older adults.
Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality
modulation were explained from differential effects of tDCS on functional coupling of the
stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study
provides first evidence for differential tDCS effects on neural network organization in young
and older adults. Anodal stimulation mainly affected coupling of sensorimotor with
ventromedial prefrontal areas in young and decoupling with posteromedial areas in older
adults.
Original languageEnglish
JournalNeuroImage
Volume176
Pages (from-to)71-82
ISSN1053-8119
DOIs
Publication statusPublished - 2018

Keywords

  • Aging
  • Eigenvector centrality mapping
  • Graph analysis
  • Resting-state functional connectivity
  • Transcranial direct current stimulation

Cite this

Antonenko, D., Nierhaus, T., Meinzer, M., Prehn, K., Thielscher, A., Ittermann, B., & Flöel, A. (2018). Age-dependent effects of brain stimulation on network centrality. NeuroImage, 176, 71-82. https://doi.org/10.1016/j.neuroimage.2018.04.038
Antonenko, Daria ; Nierhaus, Till ; Meinzer, Marcus ; Prehn, Kristin ; Thielscher, Axel ; Ittermann, Bernd ; Flöel, Agnes. / Age-dependent effects of brain stimulation on network centrality. In: NeuroImage. 2018 ; Vol. 176. pp. 71-82.
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title = "Age-dependent effects of brain stimulation on network centrality",
abstract = "Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate ageassociated differential neural tDCS effects. Three “online” tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults. Active stimulation targeted the left sensorimotor network (active electrode over left sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data analysis approach (eigenvector centrality mapping) and complementary seed-based analyses characterized neural tDCS effects. An interaction between anodal tDCS and age group was observed. Specifically, centrality in bilateral paracentral and posterior regions (precuneus, superior parietal cortex) was increased in young, but decreased in older adults. Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality modulation were explained from differential effects of tDCS on functional coupling of the stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study provides first evidence for differential tDCS effects on neural network organization in young and older adults. Anodal stimulation mainly affected coupling of sensorimotor with ventromedial prefrontal areas in young and decoupling with posteromedial areas in older adults.",
keywords = "Aging, Eigenvector centrality mapping, Graph analysis, Resting-state functional connectivity, Transcranial direct current stimulation",
author = "Daria Antonenko and Till Nierhaus and Marcus Meinzer and Kristin Prehn and Axel Thielscher and Bernd Ittermann and Agnes Fl{\"o}el",
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doi = "10.1016/j.neuroimage.2018.04.038",
language = "English",
volume = "176",
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Antonenko, D, Nierhaus, T, Meinzer, M, Prehn, K, Thielscher, A, Ittermann, B & Flöel, A 2018, 'Age-dependent effects of brain stimulation on network centrality', NeuroImage, vol. 176, pp. 71-82. https://doi.org/10.1016/j.neuroimage.2018.04.038

Age-dependent effects of brain stimulation on network centrality. / Antonenko, Daria ; Nierhaus, Till; Meinzer, Marcus; Prehn, Kristin; Thielscher, Axel; Ittermann, Bernd; Flöel, Agnes.

In: NeuroImage, Vol. 176, 2018, p. 71-82.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Age-dependent effects of brain stimulation on network centrality

AU - Antonenko, Daria

AU - Nierhaus, Till

AU - Meinzer, Marcus

AU - Prehn, Kristin

AU - Thielscher, Axel

AU - Ittermann, Bernd

AU - Flöel, Agnes

PY - 2018

Y1 - 2018

N2 - Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate ageassociated differential neural tDCS effects. Three “online” tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults. Active stimulation targeted the left sensorimotor network (active electrode over left sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data analysis approach (eigenvector centrality mapping) and complementary seed-based analyses characterized neural tDCS effects. An interaction between anodal tDCS and age group was observed. Specifically, centrality in bilateral paracentral and posterior regions (precuneus, superior parietal cortex) was increased in young, but decreased in older adults. Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality modulation were explained from differential effects of tDCS on functional coupling of the stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study provides first evidence for differential tDCS effects on neural network organization in young and older adults. Anodal stimulation mainly affected coupling of sensorimotor with ventromedial prefrontal areas in young and decoupling with posteromedial areas in older adults.

AB - Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate ageassociated differential neural tDCS effects. Three “online” tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults. Active stimulation targeted the left sensorimotor network (active electrode over left sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data analysis approach (eigenvector centrality mapping) and complementary seed-based analyses characterized neural tDCS effects. An interaction between anodal tDCS and age group was observed. Specifically, centrality in bilateral paracentral and posterior regions (precuneus, superior parietal cortex) was increased in young, but decreased in older adults. Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality modulation were explained from differential effects of tDCS on functional coupling of the stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study provides first evidence for differential tDCS effects on neural network organization in young and older adults. Anodal stimulation mainly affected coupling of sensorimotor with ventromedial prefrontal areas in young and decoupling with posteromedial areas in older adults.

KW - Aging

KW - Eigenvector centrality mapping

KW - Graph analysis

KW - Resting-state functional connectivity

KW - Transcranial direct current stimulation

U2 - 10.1016/j.neuroimage.2018.04.038

DO - 10.1016/j.neuroimage.2018.04.038

M3 - Journal article

VL - 176

SP - 71

EP - 82

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -