Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

S.N. Grell, Ulla Riber, Kirsten Tjørnehøj, Lars Erik Larsen, Peter M. H. Heegaard

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFa. levels and less virus-specific IFN gamma release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong "inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.
    Original languageEnglish
    JournalVaccine
    Volume23
    Issue number26
    Pages (from-to)3412-3423
    ISSN0264-410X
    DOIs
    Publication statusPublished - 2005

    Keywords

    • bovine respiratory syncytial virus
    • age-dependent immunity

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