TY - JOUR
T1 - Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model
AU - Grell, S.N.
AU - Riber, Ulla
AU - Tjørnehøj, Kirsten
AU - Larsen, Lars Erik
AU - Heegaard, Peter M. H.
PY - 2005
Y1 - 2005
N2 - Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFa. levels and less virus-specific IFN gamma release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong "inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.
AB - Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFa. levels and less virus-specific IFN gamma release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong "inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.
KW - bovine respiratory syncytial virus
KW - age-dependent immunity
U2 - 10.1016/j.vaccine.2005.01.094
DO - 10.1016/j.vaccine.2005.01.094
M3 - Journal article
SN - 0264-410X
VL - 23
SP - 3412
EP - 3423
JO - Vaccine
JF - Vaccine
IS - 26
ER -