Advancing biotechnology with CRISPR/Cas9: recent applications and patent landscape

Raphael Ferreira, Florian David, Jens Nielsen*

*Corresponding author for this work

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Clustered regularly interspaced short palindromic repeats (CRISPR) is poised to become one of the key scientific discoveries of the twenty-first century. Originating from prokaryotic and archaeal immune systems to counter phage invasions, CRISPR-based applications have been tailored for manipulating a broad range of living organisms. From the different elucidated types of CRISPR mechanisms, the type II system adapted from Streptococcus pyogenes has been the most exploited as a tool for genome engineering and gene regulation. In this review, we describe the different applications of CRISPR/Cas9 technology in the industrial biotechnology field. Next, we detail the current status of the patent landscape, highlighting its exploitation through different companies, and conclude with future perspectives of this technology.
Original languageEnglish
JournalJournal of Industrial Microbiology and Biotechnology
Issue number7
Pages (from-to)467-480
Publication statusPublished - 2018

Bibliographical note

© The Author(s) 2018. This article is an open access publication


  • Biotechnology
  • Applied Microbiology and Biotechnology
  • article
  • biotechnology
  • clustered regularly interspaced short palindromic repeat
  • landscape
  • patent

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