Advanced biomimetic materials for sensing and biomedical application

Xiaotong Feng

Research output: Book/ReportPh.D. thesis

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Abstract

Biomimetic materials have become a rapidly growing and enormously promising field, as they are cost-effective, easy to prepare, relatively stable.
The main goal of this multidisciplinary Ph.D. project is to fabricate biomimetic materials that are structurally or functionally similar to their biological equivalents and use them to solve real-life science problems. The work presented in the thesis includes two parts: the Molecularly Imprinted Polymers (MIPs) and pseudo-Extracellular Vesicles (pseudoEVs). MIPs-based projects focus on employing of MIPs as a tailor-made synthetic biomimetic receptor to replace the biological receptors (e.g., antibody, enzyme, etc.) either in biosensor platforms or in enzyme inhibition, as they are cheaper, more stable, and exhibit high affinity. The Pseudo-EVs project aims to develop a new biomimetic drug delivery carrier, to prolong the drug half-lives, reduce side effects, and enhance the circulating time during the drug delivery process.
In conclusion, this thesis has been shown the advantages of employing biomimetic materials to solve life science problems. We expect our developed approaches can contribute to biosensing, enzyme inhibition, and drug delivery.
Original languageEnglish
PublisherDTU Health Technology
Number of pages88
Publication statusPublished - 2020

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