Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

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  • Author: Ortiz-Alvarez, Gonzalo

    University of Paris, France

  • Author: Daclin, Marie

    University of Paris, France

  • Author: Shihavuddin, ASM

    Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science , Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Lansade, Pauline

    University of Paris, France

  • Author: Fortoul, Aurelien

    University of Paris, France

  • Author: Clavreul, Solene

    Sorbonne Universités, France

  • Author: Lalioti, Maria-Eleni

    University of Patras, Greece

  • Author: Taraviras, Stavros

    University of Patras, Greece

  • Author: Hippenmeyer, Simon

    Institute of Science and Technology Austria, Austria

  • Author: Livet, Jean

    Sorbonne Universités, France

  • Author: Meunier, Alice

    University of Paris, France

  • Author: Genovesio, Auguste

    University of Paris, France

  • Author: Spassky, Nathalie

    University of Paris, France

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Adult neural stem cells and multiciliated ependymal cells are glial cells essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis and single-cell resolution of progenitor division patterns and fate, we show that these two components of the neurogenic niche are lineally related: adult neural stem cells are sister cells to ependymal cells, whereas most ependymal cells arise from the terminal symmetric divisions of the lineage. Unexpectedly, we found that the antagonist regulators of DNA replication, GemC1 and Geminin, can tune the proportion of neural stem cells and ependymal cells. Our findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult
neural stem cells.
Original languageEnglish
JournalNeuron
Volume102
Issue number1
Pages (from-to)159-172
ISSN0896-6273
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Neural stem cells, Multiciliated ependymal cells, Radial glial cells, Cell lineage, Symmetric division, Geminin family, GemC1, Multiciliogenesis, Cell division

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