TY - JOUR
T1 - Adjuvants and delivery systems in veterinary vaccinology: current state and future developments
AU - Heegaard, Peter M. H.
AU - Dedieu, Laurence
AU - Johnson, Nicholas
AU - Potier, Marie-Frédérique Le
AU - Mockey, Michael
AU - Mutinelli, Franco
AU - Vahlenkamp, Thomas
AU - Vascellari, Marta
AU - Sørensen, Nanna Skall
N1 - The original publication is available at www.springerlink.com.
PY - 2011
Y1 - 2011
N2 - Modern adjuvants should induce strong and balanced immune responses, and it is often desirable to induce specific types of immunity. As an example, efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have low immunogenicity themselves. The development of such adjuvants may take advantage of the increased knowledge of the molecular mechanisms and factors controlling these responses. However, knowledge of such molecular details of immune mechanisms is relatively scarce for species other than humans and laboratory rodents, and in addition, there are special considerations pertaining to the use of adjuvants in veterinary animals, such as production and companion animals. With a focus on veterinary animals, this review highlights a number of approaches being pursued, including cytokines, CpG oligonucleotides, microparticles and liposomes.
AB - Modern adjuvants should induce strong and balanced immune responses, and it is often desirable to induce specific types of immunity. As an example, efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have low immunogenicity themselves. The development of such adjuvants may take advantage of the increased knowledge of the molecular mechanisms and factors controlling these responses. However, knowledge of such molecular details of immune mechanisms is relatively scarce for species other than humans and laboratory rodents, and in addition, there are special considerations pertaining to the use of adjuvants in veterinary animals, such as production and companion animals. With a focus on veterinary animals, this review highlights a number of approaches being pursued, including cytokines, CpG oligonucleotides, microparticles and liposomes.
U2 - 10.1007/s00705-010-0863-1
DO - 10.1007/s00705-010-0863-1
M3 - Journal article
VL - 156
SP - 183
EP - 202
JO - Archives of Virology, Supplement
JF - Archives of Virology, Supplement
SN - 0939-1983
IS - 2
ER -