Adjuvants and delivery systems in veterinary vaccinology: current state and future developments

Peter M. H. Heegaard, Laurence Dedieu, Nicholas Johnson, Marie-Frédérique Le Potier, Michael Mockey, Franco Mutinelli, Thomas Vahlenkamp, Marta Vascellari, Nanna Skall Sørensen

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    Modern adjuvants should induce strong and balanced immune responses, and it is often desirable to induce specific types of immunity. As an example, efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have low immunogenicity themselves. The development of such adjuvants may take advantage of the increased knowledge of the molecular mechanisms and factors controlling these responses. However, knowledge of such molecular details of immune mechanisms is relatively scarce for species other than humans and laboratory rodents, and in addition, there are special considerations pertaining to the use of adjuvants in veterinary animals, such as production and companion animals. With a focus on veterinary animals, this review highlights a number of approaches being pursued, including cytokines, CpG oligonucleotides, microparticles and liposomes.
    Original languageEnglish
    JournalArchives of Virology
    Issue number2
    Pages (from-to)183-202
    Publication statusPublished - 2011

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