Abstract
Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of
adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the
use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The
objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent
changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of
996 men and women aged 50–64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential
confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total
trans-octadecenoic acids (18 : 1t), 18 : 1 D6-10t, vaccenic acid (18 : 1 D11t) and rumenic acid (18 : 2 D9c, 11t). Data were analysed using multiple
regression with cubic spline modelling. The median proportion of total adipose tissue 18 : 1t was 1·52% (90% central range 0·98, 2·19)
in men and 1·47% (1·01, 2·19) in women. No significant associations were observed between the proportions of total 18 : 1t, 18:1 D6-10t,
vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose
tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.
adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the
use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The
objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent
changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of
996 men and women aged 50–64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential
confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total
trans-octadecenoic acids (18 : 1t), 18 : 1 D6-10t, vaccenic acid (18 : 1 D11t) and rumenic acid (18 : 2 D9c, 11t). Data were analysed using multiple
regression with cubic spline modelling. The median proportion of total adipose tissue 18 : 1t was 1·52% (90% central range 0·98, 2·19)
in men and 1·47% (1·01, 2·19) in women. No significant associations were observed between the proportions of total 18 : 1t, 18:1 D6-10t,
vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose
tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.
| Original language | English |
|---|---|
| Journal | The British Journal of Nutrition |
| Volume | 111 |
| Issue number | 7 |
| Pages (from-to) | 1283-1291 |
| ISSN | 0007-1145 |
| DOIs | |
| Publication status | Published - 2014 |
