Adipose tissue trans fatty acids and changes in body weight and waist circumference

Camilla P. Hansen, Tina L. Berentzen, Jane N. Østergaard, Christina C. Dahm, Lars Hellgren, Erik B. Schmidt, Anne Tjønneland, Thorkild I. A. Sørensen, Kim Overvad, Marianne Uhre Jakobsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of
    adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the
    use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The
    objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent
    changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of
    996 men and women aged 50–64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential
    confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total
    trans-octadecenoic acids (18 : 1t), 18 : 1 D6-10t, vaccenic acid (18 : 1 D11t) and rumenic acid (18 : 2 D9c, 11t). Data were analysed using multiple
    regression with cubic spline modelling. The median proportion of total adipose tissue 18 : 1t was 1·52% (90% central range 0·98, 2·19)
    in men and 1·47% (1·01, 2·19) in women. No significant associations were observed between the proportions of total 18 : 1t, 18:1 D6-10t,
    vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose
    tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.
    Original languageEnglish
    JournalThe British Journal of Nutrition
    Volume111
    Issue number7
    Pages (from-to)1283-1291
    ISSN0007-1145
    DOIs
    Publication statusPublished - 2014

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