Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study

Christian S. Bork*, Anne N. Lasota, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Anne Tjønneland, Kim Overvad, Erik B. Schmidt

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes. During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women. We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.
Original languageEnglish
JournalEuropean Journal of Nutrition
Number of pages10
ISSN1436-6207
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Adipose tissue content of alpha‑linolenic acid and development of peripheral artery disease: a Danish case‑cohort study
  • n-3 fatty acids
  • Peripheral arterial disease
  • case-cohort study
  • Adipose tissue

Cite this

Bork, Christian S. ; Lasota, Anne N. ; Lundbye-Christensen, Søren ; Jakobsen, Marianne Uhre ; Tjønneland, Anne ; Overvad, Kim ; Schmidt, Erik B. / Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study. In: European Journal of Nutrition. 2020.
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abstract = "The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes. During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84{\%} (interquartile range 0.73-0.94{\%}) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women. We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.",
keywords = "Adipose tissue content of alpha‑linolenic acid and development of peripheral artery disease: a Danish case‑cohort study, n-3 fatty acids, Peripheral arterial disease, case-cohort study, Adipose tissue",
author = "Bork, {Christian S.} and Lasota, {Anne N.} and S{\o}ren Lundbye-Christensen and Jakobsen, {Marianne Uhre} and Anne Tj{\o}nneland and Kim Overvad and Schmidt, {Erik B.}",
year = "2020",
doi = "10.1007/s00394-019-02159-2",
language = "English",
journal = "European Journal of Nutrition",
issn = "1436-6207",
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Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study. / Bork, Christian S.; Lasota, Anne N.; Lundbye-Christensen, Søren; Jakobsen, Marianne Uhre; Tjønneland, Anne; Overvad, Kim; Schmidt, Erik B.

In: European Journal of Nutrition, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study

AU - Bork, Christian S.

AU - Lasota, Anne N.

AU - Lundbye-Christensen, Søren

AU - Jakobsen, Marianne Uhre

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Schmidt, Erik B.

PY - 2020

Y1 - 2020

N2 - The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes. During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women. We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

AB - The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes. During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women. We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

KW - Adipose tissue content of alpha‑linolenic acid and development of peripheral artery disease: a Danish case‑cohort study

KW - n-3 fatty acids

KW - Peripheral arterial disease

KW - case-cohort study

KW - Adipose tissue

U2 - 10.1007/s00394-019-02159-2

DO - 10.1007/s00394-019-02159-2

M3 - Journal article

C2 - 31832750

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -