Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study

Lukas Vaut, Kristian E. Jensen, Guido Tosello, Ajit Khosla, Hidemitsu Furukawa*, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

146 Downloads (Pure)

Abstract

Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300μm have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods. In this feasibility study, stateof-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process.
Original languageEnglish
JournalJournal of The Electrochemical Society
Volume166
Issue number9
Pages (from-to)B3257-B3263
ISSN0013-4651
DOIs
Publication statusPublished - 2019

Cite this

@article{890b15b367874808abaa6beeb9efb3f5,
title = "Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study",
abstract = "Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300μm have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods. In this feasibility study, stateof-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process.",
author = "Lukas Vaut and Jensen, {Kristian E.} and Guido Tosello and Ajit Khosla and Hidemitsu Furukawa and Anja Boisen",
year = "2019",
doi = "10.1149/2.0421909jes",
language = "English",
volume = "166",
pages = "B3257--B3263",
journal = "Journal of The Electrochemical Society",
issn = "0013-4651",
publisher = "The Electrochemical Society",
number = "9",

}

Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study. / Vaut, Lukas; Jensen, Kristian E.; Tosello, Guido; Khosla, Ajit ; Furukawa, Hidemitsu ; Boisen, Anja.

In: Journal of The Electrochemical Society, Vol. 166, No. 9, 2019, p. B3257-B3263.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study

AU - Vaut, Lukas

AU - Jensen, Kristian E.

AU - Tosello, Guido

AU - Khosla, Ajit

AU - Furukawa, Hidemitsu

AU - Boisen, Anja

PY - 2019

Y1 - 2019

N2 - Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300μm have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods. In this feasibility study, stateof-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process.

AB - Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300μm have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods. In this feasibility study, stateof-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process.

U2 - 10.1149/2.0421909jes

DO - 10.1149/2.0421909jes

M3 - Journal article

VL - 166

SP - B3257-B3263

JO - Journal of The Electrochemical Society

JF - Journal of The Electrochemical Society

SN - 0013-4651

IS - 9

ER -