Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis

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Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis. / Frederiksen, K.S.; Hasselbalch, S.G.; Hejl, A.-M.; Law, I.; Højgaard, Liselotte; Waldemar, G.

In: Dementia and Geriatric Cognitive Disorders. Extra, Vol. 2, No. 1, 2012, p. 610-621.

Research output: Contribution to journalJournal article – Annual report year: 2012Researchpeer-review

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Frederiksen, K.S. ; Hasselbalch, S.G. ; Hejl, A.-M. ; Law, I. ; Højgaard, Liselotte ; Waldemar, G. / Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis. In: Dementia and Geriatric Cognitive Disorders. Extra. 2012 ; Vol. 2, No. 1. pp. 610-621.

Bibtex

@article{63d4cb473a2646c5bcd69604df8abd62,
title = "Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis",
abstract = "Introduction: The added diagnostic value of 11C-PiB-PET for the assessment of the accumulation of cortical beta-amyloid in memory clinic patients with uncertain diagnosis remains undetermined. Methods: All patients who underwent PiB-PET at the Copenhagen Memory Clinic between March 2008 and November 2011 were included in this uncontrolled, retrospective study. The standard diagnostic evaluation program included physical and neurological examination, cognitive and functional assessment, a cranial CT or MRI, functional imaging and cerebrospinal fluid sampling. Based on anonymized case reports, three experienced clinicians reached a consensus diagnosis and rated their confidence in the diagnosis before and after disclosure of PiB-PET ratings. PiB-PET scans were rated as either positive or negative. Results: A total of 57 patients (17 females, 30 males; age 65.7 years, range 44.2–82.6) were included in the study. Twenty-seven had a positive PiB-PET scan. At the first diagnostic evaluation, 16 patients were given a clinical Alheimer’s disease diagnosis (14 PiB positive). Of the 57 patients, 13 (23{\%}) were diagnostically reclassified after PiB-PET ratings were disclosed. The clinicians’ overall confidence in their diagnosis increased in 28 (49{\%}) patients. Conclusion: PiB-PET adds to the specialist clinical evaluation and other supplemental diagnostic investigations in the diagnostic classification of patients with uncertain diagnosis in a specialized memory clinic.Copyright {\circledC} 2012 S. Karger AG, Basel",
author = "K.S. Frederiksen and S.G. Hasselbalch and A.-M. Hejl and I. Law and Liselotte H{\o}jgaard and G. Waldemar",
year = "2012",
doi = "10.1159/000345783",
language = "English",
volume = "2",
pages = "610--621",
journal = "Dementia and Geriatric Cognitive Disorders. Extra",
issn = "1664-5464",
publisher = "S.Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis

AU - Frederiksen, K.S.

AU - Hasselbalch, S.G.

AU - Hejl, A.-M.

AU - Law, I.

AU - Højgaard, Liselotte

AU - Waldemar, G.

PY - 2012

Y1 - 2012

N2 - Introduction: The added diagnostic value of 11C-PiB-PET for the assessment of the accumulation of cortical beta-amyloid in memory clinic patients with uncertain diagnosis remains undetermined. Methods: All patients who underwent PiB-PET at the Copenhagen Memory Clinic between March 2008 and November 2011 were included in this uncontrolled, retrospective study. The standard diagnostic evaluation program included physical and neurological examination, cognitive and functional assessment, a cranial CT or MRI, functional imaging and cerebrospinal fluid sampling. Based on anonymized case reports, three experienced clinicians reached a consensus diagnosis and rated their confidence in the diagnosis before and after disclosure of PiB-PET ratings. PiB-PET scans were rated as either positive or negative. Results: A total of 57 patients (17 females, 30 males; age 65.7 years, range 44.2–82.6) were included in the study. Twenty-seven had a positive PiB-PET scan. At the first diagnostic evaluation, 16 patients were given a clinical Alheimer’s disease diagnosis (14 PiB positive). Of the 57 patients, 13 (23%) were diagnostically reclassified after PiB-PET ratings were disclosed. The clinicians’ overall confidence in their diagnosis increased in 28 (49%) patients. Conclusion: PiB-PET adds to the specialist clinical evaluation and other supplemental diagnostic investigations in the diagnostic classification of patients with uncertain diagnosis in a specialized memory clinic.Copyright © 2012 S. Karger AG, Basel

AB - Introduction: The added diagnostic value of 11C-PiB-PET for the assessment of the accumulation of cortical beta-amyloid in memory clinic patients with uncertain diagnosis remains undetermined. Methods: All patients who underwent PiB-PET at the Copenhagen Memory Clinic between March 2008 and November 2011 were included in this uncontrolled, retrospective study. The standard diagnostic evaluation program included physical and neurological examination, cognitive and functional assessment, a cranial CT or MRI, functional imaging and cerebrospinal fluid sampling. Based on anonymized case reports, three experienced clinicians reached a consensus diagnosis and rated their confidence in the diagnosis before and after disclosure of PiB-PET ratings. PiB-PET scans were rated as either positive or negative. Results: A total of 57 patients (17 females, 30 males; age 65.7 years, range 44.2–82.6) were included in the study. Twenty-seven had a positive PiB-PET scan. At the first diagnostic evaluation, 16 patients were given a clinical Alheimer’s disease diagnosis (14 PiB positive). Of the 57 patients, 13 (23%) were diagnostically reclassified after PiB-PET ratings were disclosed. The clinicians’ overall confidence in their diagnosis increased in 28 (49%) patients. Conclusion: PiB-PET adds to the specialist clinical evaluation and other supplemental diagnostic investigations in the diagnostic classification of patients with uncertain diagnosis in a specialized memory clinic.Copyright © 2012 S. Karger AG, Basel

U2 - 10.1159/000345783

DO - 10.1159/000345783

M3 - Journal article

VL - 2

SP - 610

EP - 621

JO - Dementia and Geriatric Cognitive Disorders. Extra

JF - Dementia and Geriatric Cognitive Disorders. Extra

SN - 1664-5464

IS - 1

ER -