Added Diagnostic Value of 11C-PiB-PET in Memory Clinic Patients with Uncertain Diagnosis

Research output: Contribution to journalJournal article – Annual report year: 2012Researchpeer-review

Without internal affiliation

  • Author: Frederiksen, K. S.

    Copenhagen University Hospital, Denmark

  • Author: Hasselbalch, S. G.

    Copenhagen University Hospital, Denmark

  • Author: Hejl, A.-M.

    Copenhagen University Hospital, Denmark

  • Author: Law, I.

    Copenhagen University Hospital, Denmark

  • Author: Højgaard, Liselotte

    Copenhagen University Hospital

  • Author: Waldemar, G.

    Copenhagen University Hospital, Denmark

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Introduction: The added diagnostic value of 11C-PiB-PET for the assessment of the accumulation of cortical beta-amyloid in memory clinic patients with uncertain diagnosis remains undetermined. Methods: All patients who underwent PiB-PET at the Copenhagen Memory Clinic between March 2008 and November 2011 were included in this uncontrolled, retrospective study. The standard diagnostic evaluation program included physical and neurological examination, cognitive and functional assessment, a cranial CT or MRI, functional imaging and cerebrospinal fluid sampling. Based on anonymized case reports, three experienced clinicians reached a consensus diagnosis and rated their confidence in the diagnosis before and after disclosure of PiB-PET ratings. PiB-PET scans were rated as either positive or negative. Results: A total of 57 patients (17 females, 30 males; age 65.7 years, range 44.2–82.6) were included in the study. Twenty-seven had a positive PiB-PET scan. At the first diagnostic evaluation, 16 patients were given a clinical Alheimer’s disease diagnosis (14 PiB positive). Of the 57 patients, 13 (23%) were diagnostically reclassified after PiB-PET ratings were disclosed. The clinicians’ overall confidence in their diagnosis increased in 28 (49%) patients. Conclusion: PiB-PET adds to the specialist clinical evaluation and other supplemental diagnostic investigations in the diagnostic classification of patients with uncertain diagnosis in a specialized memory clinic.
Copyright © 2012 S. Karger AG, Basel
Original languageEnglish
JournalDementia and Geriatric Cognitive Disorders. Extra
Volume2
Issue number1
Pages (from-to)610-621
ISSN1664-5464
DOIs
Publication statusPublished - 2012
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI

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