Adapting to the airways: Metabolic requirements of Pseudomonas aeruginosa during the infection of cystic fibrosis patients

Ruggero La Rosa*, Helle Krogh Johansen, Søren Molin

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Pseudomonas aeruginosa is one of the major causes of morbidity and mortality of cystic fibrosis patients. During the infection, the bacteria colonize the nutritional rich lung mucus, which is present in the airway secretions in the patients, and they adapt their phenotype accordingly to the lung environment. In the airways, P. aeruginosa undergoes a broad metabolic rewiring as a consequence of the nutritional and stressful complexity of the lungs. However, the role of such metabolic rewiring on the infection outcome is poorly understood. Here, we review the metabolic evolution of clinical strains of P. aeruginosa during a cystic fibrosis lung infection and the metabolic functions operating in vivo under patho-physiological conditions. Finally, we discuss the perspective of modeling the cystic fibrosis environment using genome scale metabolic models of P. aeruginosa. Understanding the physiological changes occurring during the infection may pave the way to a more effective treatment for P. aeruginosa lung infections.
Original languageEnglish
Article number234
JournalMetabolites
Volume9
Issue number10
ISSN2218-1989
DOIs
Publication statusPublished - 2019

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