Acylation of Glucagon-like peptide-2: Interaction with lipid membranes and in vitro intestinal permeability

Sofie Trier, Lars Linderoth, Simon Bjerregaard, Thomas Lars Andresen, Ulrik Lytt Rahbek

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Abstract

These results show that membrane interactions play a prominent role during intestinal translocation of an acylated peptide. Acylation benefits permeation for shorter and medium chains due to increased membrane interactions, however, for longer chains insertion in the membrane becomes dominant and hinders translocation, i.e. the peptides get 'stuck' in the cell membrane. Applying a transcellular absorption enhancer increases the dynamics of membrane insertion and detachment by fluidizing the membrane, thus facilitating its effects primarily on membrane associated peptides.
Original languageEnglish
JournalP L o S One
Volume9
Issue number10
Pages (from-to)e109939
Number of pages10
ISSN1932-6203
DOIs
Publication statusPublished - 2014

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